nono-1 NOPS domain-containing protein;RRM domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nono-1
Official Full Name: NOPS domain-containing protein;RRM domain-containing protein
Primary source: WormBase:WBGene00017778
Locus tag: CELE_F25B5.7
See related: AllianceGenome:WB:WBGene00017778
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable RNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Located in nucleus. Is expressed in body wall musculature and reproductive system. Human ortholog(s) of this gene implicated in cardiomyopathy; intellectual disability; and syndromic X-linked intellectual disability 34. Orthologous to several human genes including PSPC1 (paraspeckle component 1) and SFPQ (splicing factor proline and glutamine rich). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See nono-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 7

Sequence:: Chromosome: III; NC_003281.10 (5953557..5958246, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results show that the structure of NONO-1 is dimeric and reveal that DBHS domain architecture is consistent within the family from invertebrates to vertebrates.
Title: Caenorhabditis elegans NONO-1: Insights into DBHS protein structure, architecture, and function.
CDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication
Title: CDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F25B5.7 (e-PCR)
- UniSTS:314124

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: NOPS domain-containing protein;RRM domain-containing protein

NP_001359971.1

Confirmed by transcript evidence

NP_001379859.1

Confirmed by transcript evidence

NP_498295.3

Confirmed by transcript evidence

NP_871666.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

5953557..5958246 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065894.5 → NP_498295.3 RRM domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498295.3

Status: REVIEWED

UniProtKB/TrEMBL

B3GWA1

Conserved Domains (3) summary

cd12931
Location:260 → 349

eNOPS_SF; NOPS domain, including C-terminal helical extension region, in the p54nrb/PSF/PSP1 family

cd12332
Location:115 → 184

RRM1_p54nrb_like; RNA recognition motif 1 in the p54nrb/PSF/PSP1 family

cd12333
Location:190 → 269

RRM2_p54nrb_like; RNA recognition motif 2 in the p54nrb/PSF/PSP1 family
NM_001372604.3 → NP_001359971.1 NOPS domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

B3GWA0

Conserved Domains (1) summary

cl06904
Location:1 → 69

eNOPS_SF; NOPS domain, including C-terminal helical extension region, in the p54nrb/PSF/PSP1 family
NM_001392114.1 → NP_001379859.1 RRM domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q95QI9

Conserved Domains (2) summary

PRK10811
Location:2 → 45

rne; ribonuclease E; Reviewed

cl17169
Location:115 → 157

RRM_SF; RNA recognition motif (RRM) superfamily
NM_181937.5 → NP_871666.1 RRM domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_871666.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8I7K5

Conserved Domains (3) summary

cd12931
Location:260 → 349

eNOPS_SF; NOPS domain, including C-terminal helical extension region, in the p54nrb/PSF/PSP1 family

cd12332
Location:115 → 184

RRM1_p54nrb_like; RNA recognition motif 1 in the p54nrb/PSF/PSP1 family

cd12333
Location:190 → 269

RRM2_p54nrb_like; RNA recognition motif 2 in the p54nrb/PSF/PSP1 family