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    cpr-6 Cathepsin B-like cysteine proteinase 6 [ Caenorhabditis elegans ]

    Gene ID: 180931, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cpr-6
    Official Full Name
    Cathepsin B-like cysteine proteinase 6
    Primary source
    WormBase:WBGene00000786
    Locus tag
    CELE_C25B8.3
    See related
    AllianceGenome:WB:WBGene00000786
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Located in lysosome. Human ortholog(s) of this gene implicated in diabetes mellitus. Orthologous to human CTSB (cathepsin B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cpr-6 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    8
    Sequence:
    Chromosome: X; NC_003284.9 (6607207..6609045)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene tRNA Neighboring gene Claudin domain-containing protein 1 Neighboring gene Claudin domain-containing protein 2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene C-type lectin domain-containing protein Neighboring gene Potassium voltage-gated channel subfamily KQT member 5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of four developmentally regulated cathepsin B-like cysteine protease genes from the nematode Caenorhabditis elegans. Larminie CG, et al. DNA Cell Biol, 1996 Jan. PMID 8561899
    2. Sequential action of Caenorhabditis elegans Rab GTPases regulates phagolysosome formation during apoptotic cell degradation. Guo P, et al. Proc Natl Acad Sci U S A, 2010 Oct 19. PMID 20921409, Free PMC Article
    3. Exploring transcriptional conservation between Ancylostoma caninum and Haemonchus contortus by oligonucleotide microarray and bioinformatic analyses. Cantacessi C, et al. Mol Cell Probes, 2009 Feb. PMID 18977290
    4. Identification of the hydrophobic glycoproteins of Caenorhabditis elegans. Fan X, et al. Glycobiology, 2005 Oct. PMID 15888633
    5. An intracellular serpin regulates necrosis by inhibiting the induction and sequelae of lysosomal injury. Luke CJ, et al. Cell, 2007 Sep 21. PMID 17889653, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis involved in protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Cathepsin B-like cysteine proteinase 6
    NP_741818.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      6607207..6609045
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171708.8 → NP_741818.1  Cathepsin B-like cysteine proteinase 6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741818.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P43510
      Conserved Domains (2) summary
      cd02620
      Location:106 → 355
      Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
      pfam08127
      Location:44 → 82
      Propeptide_C1; Peptidase family C1 propeptide
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43510.1

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