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    K04C2.2 DNA polymerase V [ Caenorhabditis elegans ]

    Gene ID: 175960, updated on 9-Dec-2024

    Summary

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    Official Symbol
    K04C2.2
    Official Full Name
    DNA polymerase V
    Primary source
    WormBase:WBGene00019380
    Locus tag
    CELE_K04C2.2
    See related
    AllianceGenome:WB:WBGene00019380
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable sequence-specific DNA binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to be active in nucleolus. Orthologous to human MYBBP1A (MYB binding protein 1a). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See K04C2.2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    17
    Sequence:
    Chromosome: III; NC_003281.10 (6889774..6895089)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene BRCA1-associated RING domain protein 1 Neighboring gene ncRNA Neighboring gene tRNA-Gly Neighboring gene tRNA-Gly Neighboring gene ncRNA Neighboring gene INSulin related Neighboring gene F-box domain-containing protein Neighboring gene DNA repair protein brc-2 Neighboring gene DSBA-like thioredoxin domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. COP9 signalosome component CSN-5 stabilizes PUF proteins FBF-1 and FBF-2 in Caenorhabditis elegans germline stem and progenitor cells. Osterli E, et al. Genetics, 2024 May 7. PMID 38427913,
    2. β-Integrin de-phosphorylation by the Density-Enhanced Phosphatase DEP-1 attenuates EGFR signaling in C. elegans. Walser M, et al. PLoS Genet, 2017 Jan. PMID 28135265, Free PMC Article
    3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA polymerase V
    NP_498499.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      6889774..6895089
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066098.7 → NP_498499.1  DNA polymerase V [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498499.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21210
      Conserved Domains (1) summary
      pfam04931
      Location:44 → 705
      DNA_pol_phi; DNA polymerase phi
    Nucleotide Protein
    Heading Accession and Version

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