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    pezo-1 Piezo-type mechanosensitive ion channel component 1 [ Caenorhabditis elegans ]

    Gene ID: 182492, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pezo-1
    Official Full Name
    Piezo-type mechanosensitive ion channel component 1
    Primary source
    WormBase:WBGene00007505
    Locus tag
    CELE_C10C5.1
    See related
    AllianceGenome:WB:WBGene00007505
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mechanosensitive monoatomic ion channel activity and monoatomic cation channel activity. Involved in flagellated sperm motility; positive regulation of brood size; and positive regulation of ovulation. Located in plasma membrane. Is expressed in several structures, including germ line; gonad; muscle cell; pharynx; and sperm. Used to study hemolytic anemia. Human ortholog(s) of this gene implicated in dehydrated hereditary stomatocytosis 1; distal arthrogryposis type 3; distal arthrogryposis type 5; and hereditary lymphedema. Orthologous to several human genes including PIEZO1 (piezo type mechanosensitive ion channel component 1 (Er blood group)). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pezo-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    35
    Sequence:
    Chromosome: IV; NC_003282.8 (9343359..9366511, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Vacuolar protein sorting-associated protein 26 Neighboring gene Phosphatidylinositol N-acetylglucosaminyltransferase subunit C Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene F-box domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Clearance of extracellular human amyloid-β aggregates in C. elegans by nutraceutical and pharmaceutical interventions. Sharma A, et al. MicroPubl Biol, 2024. PMID 38287930, Free PMC Article
    2. The structure of a conserved piezo channel domain reveals a topologically distinct β sandwich fold. Kamajaya A, et al. Structure, 2014 Oct 7. PMID 25242456, Free PMC Article
    3. Caenorhabditis elegans PIEZO channel coordinates multiple reproductive tissues to govern ovulation. Bai X, et al. Elife, 2020 Jun 3. PMID 32490809, Free PMC Article
    4. Worms find PEZO-1's function easy to swallow. Short B. J Gen Physiol, 2022 Jan 3. PMID 34889959, Free PMC Article
    5. Distinct mechanoreceptor pezo-1 isoforms modulate food intake in the nematode Caenorhabditis elegans. Hughes K, et al. G3 (Bethesda), 2022 Mar 4. PMID 35100363, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Distinct mechanoreceptor pezo-1 isoforms modulate food intake in the nematode Caenorhabditis elegans.
      Title: Distinct mechanoreceptor pezo-1 isoforms modulate food intake in the nematode Caenorhabditis elegans.
    2. C. elegans PEZO-1 is a mechanosensitive ion channel involved in food sensation.
      Title: C. elegans PEZO-1 is a mechanosensitive ion channel involved in food sensation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables mechanosensitive monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mechanosensitive monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to mechanical stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in detection of mechanical stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic cation transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of brood size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of ovulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to mechanical stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Piezo-type mechanosensitive ion channel component 1
    NP_001255385.2
    • Confirmed by transcript evidence
    NP_001255386.2
    • Partially confirmed by transcript evidence
    NP_001255387.2
    • Confirmed by transcript evidence
    NP_001255388.2
    • Confirmed by transcript evidence
    NP_001255389.2
    • Confirmed by transcript evidence
    NP_001255390.2
    • Confirmed by transcript evidence
    NP_001255391.2
    • Confirmed by transcript evidence
    NP_001293677.1
    • Confirmed by transcript evidence
    NP_001293979.1
    • Confirmed by transcript evidence
    NP_001293980.1
    • Confirmed by transcript evidence
    NP_001293981.1
    • Confirmed by transcript evidence
    NP_001368483.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      9343359..9366511 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268461.4 → NP_001255390.2  Piezo-type mechanosensitive ion channel component 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255390.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6KRJ3
      Conserved Domains (3) summary
      pfam12166
      Location:1940 → 2393
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:1202 → 1415
      PIEZO; Piezo
      cl21590
      Location:185 → 269
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

    2. NM_001268460.4 → NP_001255389.2  Piezo-type mechanosensitive ion channel component 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255389.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q17897
      Conserved Domains (3) summary
      pfam12166
      Location:1978 → 2431
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:1240 → 1453
      PIEZO; Piezo
      cl21590
      Location:185 → 269
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

    3. NM_001268459.3 → NP_001255388.2  Piezo-type mechanosensitive ion channel component 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255388.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9G2S2
      Conserved Domains (3) summary
      pfam12166
      Location:1942 → 2395
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:1204 → 1417
      PIEZO; Piezo
      cl21590
      Location:185 → 269
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

    4. NM_001307050.3 → NP_001293979.1  Piezo-type mechanosensitive ion channel component 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293979.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061AE33
      Conserved Domains (3) summary
      pfam12166
      Location:1942 → 2395
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:1204 → 1417
      PIEZO; Piezo
      cl21590
      Location:185 → 269
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

    5. NM_001268457.4 → NP_001255386.2  Piezo-type mechanosensitive ion channel component 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255386.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B9WRT3
      Conserved Domains (2) summary
      pfam12166
      Location:1270 → 1723
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:506 → 745
      PIEZO; Piezo

    6. NM_001307052.3 → NP_001293981.1  Piezo-type mechanosensitive ion channel component 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293981.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061AJB7
      Conserved Domains (3) summary
      pfam12166
      Location:1944 → 2397
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:1206 → 1419
      PIEZO; Piezo
      cl21590
      Location:185 → 269
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

    7. NM_001268462.4 → NP_001255391.2  Piezo-type mechanosensitive ion channel component 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255391.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9G2S3
      Conserved Domains (3) summary
      pfam12166
      Location:1980 → 2433
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:1242 → 1455
      PIEZO; Piezo
      cl21590
      Location:185 → 269
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

    8. NM_001268458.4 → NP_001255387.2  Piezo-type mechanosensitive ion channel component 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255387.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      D0VWN8
      Conserved Domains (3) summary
      pfam12166
      Location:1980 → 2433
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:1242 → 1455
      PIEZO; Piezo
      cl21590
      Location:185 → 269
      PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

    9. NM_001307051.3 → NP_001293980.1  Piezo-type mechanosensitive ion channel component 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293980.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A061ACU2, A0A061AE33, A0A061AJB7, A0A061AL01, A0A067XG44, B9WRT3, C6KRJ3, D0VWN8, H9G2S2, H9G2S3, O01260, Q17897
      Conserved Domains (2) summary
      pfam12166
      Location:1982 → 2435
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:1244 → 1460
      PIEZO; Piezo

    10. NM_001380408.1 → NP_001368483.1  Piezo-type mechanosensitive ion channel component 1 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      pfam12166
      Location:1226 → 1679
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:488 → 704
      PIEZO; Piezo

    11. NM_001268456.4 → NP_001255385.2  Piezo-type mechanosensitive ion channel component 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255385.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O01260
      Conserved Domains (2) summary
      pfam12166
      Location:1244 → 1697
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:506 → 719
      PIEZO; Piezo

    12. NM_001306748.3 → NP_001293677.1  Piezo-type mechanosensitive ion channel component 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293677.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A067XG44
      Conserved Domains (2) summary
      pfam12166
      Location:578 → 1031
      Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain
      pfam15917
      Location:1 → 56
      PIEZO; Piezo
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A061ACU2.1

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