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    vps-37 VPS37 C-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 178944, updated on 9-Dec-2024

    Summary

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    Official Symbol
    vps-37
    Official Full Name
    VPS37 C-terminal domain-containing protein
    Primary source
    WormBase:WBGene00016990
    Locus tag
    CELE_CD4.4
    See related
    AllianceGenome:WB:WBGene00016990
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in receptor catabolic process. Located in cytosol and endosome membrane. Part of ESCRT I complex. Is expressed in several structures, including excretory cell; intestine; nervous system; pharynx; and reproductive system. Orthologous to several human genes including VPS37B (VPS37B subunit of ESCRT-I). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See vps-37 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    3
    Sequence:
    Chromosome: V; NC_003283.11 (5592700..5593612)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene MAM domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Small ribosomal subunit protein uS10 domain-containing protein Neighboring gene Deoxyribonuclease TATDN1 Neighboring gene HIT-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MVB-12, a fourth subunit of metazoan ESCRT-I, functions in receptor downregulation. Audhya A, et al. PLoS One, 2007 Sep 26. PMID 17895996, Free PMC Article
    2. Differential physiological roles of ESCRT complexes in Caenorhabditis elegans. Kim DW, et al. Mol Cells, 2011 Jun. PMID 21688204, Free PMC Article
    3. Filamin FLN-2 promotes MVB biogenesis by mediating vesicle docking on the actin cytoskeleton. Shi L, et al. J Cell Biol, 2022 Jul 4. PMID 35575797, Free PMC Article
    4. Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants. Samuelson AV, et al. Genes Dev, 2007 Nov 15. PMID 18006689, Free PMC Article
    5. trim-21 promotes proteasomal degradation of CED-1 for apoptotic cell clearance in C. elegans. Yuan L, et al. Elife, 2022 Aug 5. PMID 35929733, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to vacuole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in receptor catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of ESCRT I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ESCRT I complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ESCRT I complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    VPS37 C-terminal domain-containing protein
    NP_504474.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      5592700..5593612
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072073.5 → NP_504474.1  VPS37 C-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504474.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O44158
      Conserved Domains (1) summary
      pfam07200
      Location:23 → 167
      Mod_r; Modifier of rudimentary (Mod(r)) protein
    Nucleotide Protein
    Heading Accession and Version

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