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    abtm-1 ABC transmembrane type-1 domain-containing protein;Iron-sulfur clusters transporter ABCB7, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 171807, updated on 9-Dec-2024

    Summary

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    Official Symbol
    abtm-1
    Official Full Name
    ABC transmembrane type-1 domain-containing protein;Iron-sulfur clusters transporter ABCB7, mitochondrial
    Primary source
    WormBase:WBGene00022281
    Locus tag
    CELE_Y74C10AR.3
    See related
    AllianceGenome:WB:WBGene00022281
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATPase-coupled transmembrane transporter activity. Involved in intracellular iron ion homeostasis. Located in mitochondrion. Is expressed in coelomocyte; hypodermis; intestine; and spermatheca. Used to study X-linked sideroblastic anemia with ataxia. Human ortholog(s) of this gene implicated in X-linked sideroblastic anemia with ataxia. Orthologous to human ABCB7 (ATP binding cassette subfamily B member 7). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See abtm-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    8
    Sequence:
    Chromosome: I; NC_003279.8 (2472060..2485391, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Innexin-19 Neighboring gene Transmembrane protein 50A Neighboring gene Conserved secreted protein Neighboring gene Eukaryotic translation initiation factor 3 subunit I;Serine-threonine kinase receptor-associated protein Neighboring gene ATP-dependent RNA helicase;ATP-dependent rRNA helicase SPB4-like C-terminal extension domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Disruption of the ATP-binding cassette B7 (ABTM-1/ABCB7) induces oxidative stress and premature cell death in Caenorhabditis elegans. González-Cabo P, et al. J Biol Chem, 2011 Jun 17. PMID 21464130, Free PMC Article
    2. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article
    3. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article
    4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular iron ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to chemical IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ABC transmembrane type-1 domain-containing protein;Iron-sulfur clusters transporter ABCB7, mitochondrial
    NP_001021830.1
    • Confirmed by transcript evidence
    NP_001293306.1
    • Partially confirmed by transcript evidence
    NP_001380172.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      2472060..2485391 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001026659.3 → NP_001021830.1  Iron-sulfur clusters transporter ABCB7, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021830.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G4SRS5, Q3V5J1, Q71JP9
      Conserved Domains (3) summary
      COG5265
      Location:172 → 667
      ATM1; ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]
      cl00549
      Location:104 → 387
      ABC_membrane; ABC transporter transmembrane region
      cl21455
      Location:437 → 670
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001306377.3 → NP_001293306.1  ABC transmembrane type-1 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293306.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061AJH7
      Conserved Domains (1) summary
      cl21455
      Location:1 → 60
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. NM_001393067.1 → NP_001380172.1  ABC transmembrane type-1 domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061ACG9, Q71JP8
      Conserved Domains (2) summary
      cd07346
      Location:103 → 126
      ABC_6TM_exporters; TM helix 1 [structural motif]
      cl38913
      Location:103 → 140
      ABC_6TM_exporters; Six-transmembrane helical domain of the ATP-binding cassette transporters
    Nucleotide Protein
    Heading Accession and Version

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