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    tmem-132 Transmembrane protein 132 homolog [ Caenorhabditis elegans ]

    Gene ID: 175386, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tmem-132
    Official Full Name
    Transmembrane protein 132 homolog
    Primary source
    WormBase:WBGene00022175
    Locus tag
    CELE_Y71H2AM.10
    See related
    AllianceGenome:WB:WBGene00022175
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in dopaminergic neuron differentiation. Predicted to be located in membrane. Is expressed in neurons. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 99. Orthologous to several human genes including TMEM132B (transmembrane protein 132B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tmem-132 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    14
    Sequence:
    Chromosome: III; NC_003281.10 (2707726..2716614, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene EF-hand domain-containing protein Neighboring gene CX domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Proton-coupled zinc antiporter SLC30A9, mitochondrial Neighboring gene protein-histidine N-methyltransferase Neighboring gene tRNA-Pro Neighboring gene Peptidase M20 dimerization domain-containing protein Neighboring gene Cyclin N-terminal domain-containing protein Neighboring gene Ras-related protein Rab-18

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The C. elegans homolog of human panic-disorder risk gene TMEM132D orchestrates neuronal morphogenesis through the WAVE-regulatory complex. Wang X, et al. Mol Brain, 2021 Mar 16. PMID 33726789, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The C. elegans homolog of human panic-disorder risk gene TMEM132D orchestrates neuronal morphogenesis through the WAVE-regulatory complex.
      Title: The C. elegans homolog of human panic-disorder risk gene TMEM132D orchestrates neuronal morphogenesis through the WAVE-regulatory complex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dopaminergic neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Transmembrane protein 132 homolog
    NP_497605.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      2707726..2716614 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065204.5 → NP_497605.2  Transmembrane protein 132 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497605.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9BL47
      Conserved Domains (1) summary
      pfam16070
      Location:356 → 698
      TMEM132; Transmembrane protein family 132
    Nucleotide Protein
    Heading Accession and Version

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