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    rga-4 Rho-GAP domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 178629, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rga-4
    Official Full Name
    Rho-GAP domain-containing protein
    Primary source
    WormBase:WBGene00022286
    Locus tag
    CELE_Y75B7AL.4
    See related
    AllianceGenome:WB:WBGene00022286
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables GTPase activator activity. Involved in asymmetric protein localization involved in cell fate determination; cortical actin cytoskeleton organization; and regulation of actin filament-based process. Is expressed in embryonic cell and germ line. Orthologous to human ARHGAP11A (Rho GTPase activating protein 11A). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rga-4 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    9
    Sequence:
    Chromosome: V; NC_003283.11 (1373120..1383256, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene C2 domain-containing protein Neighboring gene ncRNA Neighboring gene DUF148 domain-containing protein Neighboring gene C2 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A conserved RhoGAP limits M phase contractility and coordinates with microtubule asters to confine RhoA during cytokinesis. Zanin E, et al. Dev Cell, 2013 Sep 16. PMID 24012485, Free PMC Article
    2. Functions of the novel RhoGAP proteins RGA-3 and RGA-4 in the germ line and in the early embryo of C. elegans. Schmutz C, et al. Development, 2007 Oct. PMID 17728351
    3. The Rho GTPase-activating proteins RGA-3 and RGA-4 are required to set the initial size of PAR domains in Caenorhabditis elegans one-cell embryos. Schonegg S, et al. Proc Natl Acad Sci U S A, 2007 Sep 18. PMID 17848508, Free PMC Article
    4. The RhoGAP activity of CYK-4/MgcRacGAP functions non-canonically by promoting RhoA activation during cytokinesis. Zhang D, et al. Elife, 2015 Aug 7. PMID 26252513, Free PMC Article
    5. The TAO kinase KIN-18 regulates contractility and establishment of polarity in the C. elegans embryo. Spiga FM, et al. Dev Biol, 2013 Jan 1. PMID 23064028

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. identified two redundant GTPase activating proteins (GAPs) - RGA-3 and RGA-4 - that regulate Rho GTPase function at the plasma membrane in early embryos
      Title: Functions of the novel RhoGAP proteins RGA-3 and RGA-4 in the germ line and in the early embryo of C. elegans.
    2. we identify the GTPase-activating proteins (GAPs) RGA-4, which regulate the activity of the small GTPase RHO-1.
      Title: The Rho GTPase-activating proteins RGA-3 and RGA-4 are required to set the initial size of PAR domains in Caenorhabditis elegans one-cell embryos.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activator activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in asymmetric protein localization involved in cell fate determination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cortical actin cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of actin filament-based process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of actin filament-based process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rho-GAP domain-containing protein
    NP_001041201.1
    • Confirmed by transcript evidence
    NP_001041202.1
    • Confirmed by transcript evidence
    NP_001300288.1
    • Partially confirmed by transcript evidence
    NP_001300289.1
    • Confirmed by transcript evidence
    NP_001300290.1
    • Confirmed by transcript evidence
    NP_001300291.1
    • Confirmed by transcript evidence
    NP_001300292.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      1373120..1383256 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001047736.4 → NP_001041201.1  Rho-GAP domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041201.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q965S4
      Conserved Domains (1) summary
      smart00324
      Location:63 → 230
      RhoGAP; GTPase-activator protein for Rho-like GTPases

    2. NM_001313359.5 → NP_001300288.1  Rho-GAP domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AW57
      Conserved Domains (1) summary
      smart00324
      Location:63 → 230
      RhoGAP; GTPase-activator protein for Rho-like GTPases

    3. NM_001047737.3 → NP_001041202.1  Rho-GAP domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041202.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KZS7
      Conserved Domains (1) summary
      smart00324
      Location:63 → 235
      RhoGAP; GTPase-activator protein for Rho-like GTPases

    4. NM_001313361.3 → NP_001300290.1  Rho-GAP domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AT49
      Conserved Domains (1) summary
      smart00324
      Location:1 → 150
      RhoGAP; GTPase-activator protein for Rho-like GTPases

    5. NM_001313360.3 → NP_001300289.1  Rho-GAP domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AYE4
      Conserved Domains (1) summary
      smart00324
      Location:1 → 150
      RhoGAP; GTPase-activator protein for Rho-like GTPases

    6. NM_001313363.3 → NP_001300292.1  Rho-GAP domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ASJ8

    7. NM_001313362.3 → NP_001300291.1  Rho-GAP domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AVE9
    Nucleotide Protein
    Heading Accession and Version

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