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    tufm-1 Elongation factor Tu, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 175398, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tufm-1
    Official Full Name
    Elongation factor Tu, mitochondrial
    Primary source
    WormBase:WBGene00007000
    Locus tag
    CELE_Y71H2AM.23
    See related
    AllianceGenome:WB:WBGene00007000
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable translation elongation factor activity. Predicted to be involved in mitochondrial translational elongation. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 4. Orthologous to human TUFM (Tu translation elongation factor, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tufm-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (2812143..2814969, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Peptidase C1A papain C-terminal domain-containing protein Neighboring gene E3 ubiquitin-protein ligase E3D Neighboring gene Phosphatidylinositol-4,5-bisphosphate 4-phosphatase Neighboring gene N(6)-L-threonylcarbamoyladenine synthase Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. T-armless tRNAs and elongated elongation factor Tu. Ohtsuki T, et al. IUBMB Life, 2007 Feb. PMID 17454297
    2. A unique serine-specific elongation factor Tu found in nematode mitochondria. Ohtsuki T, et al. Nat Struct Biol, 2002 Sep. PMID 12145639
    3. A unique tRNA recognition mechanism of Caenorhabditis elegans mitochondrial EF-Tu2. Suematsu T, et al. Nucleic Acids Res, 2005. PMID 16113240, Free PMC Article
    4. A protein extension to shorten RNA: elongated elongation factor-Tu recognizes the D-arm of T-armless tRNAs in nematode mitochondria. Sakurai M, et al. Biochem J, 2006 Oct 15. PMID 16859488, Free PMC Article
    5. Identification of the residues involved in the unique serine specificity of Caenorhabditis elegans mitochondrial EF-Tu2. Sato A, et al. Biochemistry, 2006 Sep 12. PMID 16953577

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation elongation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Elongation factor Tu, mitochondrial
    NP_497623.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      2812143..2814969 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065222.7 → NP_497623.1  Elongation factor Tu, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497623.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECM6, Q7JQD2
      Conserved Domains (1) summary
      PRK00049
      Location:41 → 438
      PRK00049; elongation factor Tu; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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