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    daf-14 Smad-related protein daf-14 [ Caenorhabditis elegans ]

    Gene ID: 177908, updated on 9-Dec-2024

    Summary

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    Official Symbol
    daf-14
    Official Full Name
    Smad-related protein daf-14
    Primary source
    WormBase:WBGene00000910
    Locus tag
    CELE_F01G10.8
    See related
    AllianceGenome:WB:WBGene00000910
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; I-SMAD binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including determination of adult lifespan; egg-laying behavior; and negative regulation of dauer larval development. Predicted to be part of heteromeric SMAD protein complex. Is expressed in several structures, including anal sphincter muscle; excretory duct cell; intestine; nerve ring; and phasmid sheath cell. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See daf-14 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    6
    Sequence:
    Chromosome: IV; NC_003282.8 (10250627..10255852)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene transketolase Neighboring gene BPI2 domain-containing protein Neighboring gene Ground-like domain-containing protein Neighboring gene ncRNA Neighboring gene Nematode Specific Peptide family, group D

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Caenorhabditis elegans dauer larva: developmental effects of pheromone, food, and temperature. Golden JW, et al. Dev Biol, 1984 Apr. PMID 6706004
    2. Chemosensory neurons function in parallel to mediate a pheromone response in C. elegans. Schackwitz WS, et al. Neuron, 1996 Oct. PMID 8893028
    3. Critical periods in the development of the Caenorhabditis elegans dauer larva. Swanson MM, et al. Dev Biol, 1981 May. PMID 7250500
    4. The DAF-3 Smad protein antagonizes TGF-beta-related receptor signaling in the Caenorhabditis elegans dauer pathway. Patterson GI, et al. Genes Dev, 1997 Oct 15. PMID 9334330, Free PMC Article
    5. A common muscarinic pathway for diapause recovery in the distantly related nematode species Caenorhabditis elegans and Ancylostoma caninum. Tissenbaum HA, et al. Proc Natl Acad Sci U S A, 2000 Jan 4. PMID 10618440, Free PMC Article

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables I-SMAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SMAD protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in anatomical structure morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dauer larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in dauer larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in egg-laying behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of dauer larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pigment accumulation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in pigment accumulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in post-embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of dauer larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of dauer larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of developmental process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of multicellular organismal process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in social behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of heteromeric SMAD protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Smad-related protein daf-14
    NP_001255475.1
    • Confirmed by transcript evidence
    NP_001255476.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      10250627..10255852
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268546.3 → NP_001255475.1  Smad-related protein daf-14 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255475.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F5GUE5, G5EEP2
      Conserved Domains (1) summary
      smart00524
      Location:133 → 308
      DWB; Domain B in dwarfin family proteins

    2. NM_001268547.2 → NP_001255476.1  Smad-related protein daf-14 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255476.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EEP2
      Conserved Domains (1) summary
      smart00524
      Location:89 → 264
      DWB; Domain B in dwarfin family proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F5GUE5.1

    Gene LinkOut

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