rab-3 Ras-related protein Rab-3 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rab-3
Official Full Name: Ras-related protein Rab-3
Primary source: WormBase:WBGene00004267
Locus tag: CELE_C18A3.6
See related: AllianceGenome:WB:WBGene00004267
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable GTPase activity and myosin V binding activity. Involved in several processes, including cholinergic synaptic transmission; positive regulation of anterior/posterior axon guidance; and ventral cord development. Located in neuron projection and synaptic vesicle. Is expressed in nervous system and uv1. Used to study alcohol use disorder and epilepsy. Orthologous to several human genes including RAB3A (RAB3A, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See rab-3 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 6

Sequence:: Chromosome: II; NC_003280.10 (5721767..5727853, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our data suggest that AEX-3 activates RAB-3 in the context of AVG axon navigation.
Title: Pioneer Axon Navigation Is Controlled by AEX-3, a Guanine Nucleotide Exchange Factor for RAB-3 in Caenorhabditis elegans.
Data show that without synaptotagmin 1, the tight coupling between vesicle exocytosis and Rab3 GTP-binding protein membrane disassociation is disrupted.
Title: Synaptotagmin 1 directs repetitive release by coupling vesicle exocytosis to the Rab3 cycle.
rep-1 does not functions in the RAB-3 pathway, for synaptic transmission at neuromuscular junctions
Title: Caenorhabditis elegans Rab escort protein (REP-1) differently regulates each Rab protein function and localization in a tissue-dependent manner.
These data suggest a conserved role of RAB-3-/RAB3A-regulated neurotransmitter release in ethanol-related behaviors.
Title: Loss of RAB-3/A in Caenorhabditis elegans and the mouse affects behavioral response to ethanol.
Vesicles targeted to the presynaptic density by RAB-3/UNC-10 interactions are ideally positioned for efficient calcium-dependent release.
Title: Direct interactions between C. elegans RAB-3 and Rim provide a mechanism to target vesicles to the presynaptic density.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C18A3.6 (e-PCR)
- UniSTS:313705

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables myosin V binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in exocytosis	IEA Inferred from Electronic Annotation more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in mating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of anterior/posterior axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of anterior/posterior axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of nematode pharyngeal pumping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic transmission, GABAergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic transmission, cholinergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventral cord development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ventral cord development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Ras-related protein Rab-3

NP_001021973.1

Confirmed by transcript evidence

NP_001367527.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

5721767..5727853 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001026802.4 → NP_001021973.1 Ras-related protein Rab-3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021973.1

Status: REVIEWED

UniProtKB/TrEMBL

I7F488, Q95QV3

Conserved Domains (2) summary

smart00175
Location:37 → 197

RAB; Rab subfamily of small GTPases

cd01865
Location:36 → 200

Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D
NM_001381435.3 → NP_001367527.1 Ras-related protein Rab-3 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q94986

UniProtKB/TrEMBL

I7F488

Conserved Domains (1) summary

cd01865
Location:22 → 186

Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D