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    adt-3 Peptidase M12B domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180675, updated on 9-Dec-2024

    Summary

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    Official Symbol
    adt-3
    Official Full Name
    Peptidase M12B domain-containing protein
    Primary source
    WormBase:WBGene00020567
    Locus tag
    CELE_T19D2.1
    See related
    AllianceGenome:WB:WBGene00020567
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in extracellular matrix organization and proteolysis. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Is expressed in rectal epithelium and rectal gland cell. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See adt-3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    22
    Sequence:
    Chromosome: X; NC_003284.9 (3931650..3937897)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene RING-type domain-containing protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene TYR_PHOSPHATASE_2 domain-containing protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Broadly conserved roles of TMEM131 family proteins in intracellular collagen assembly and secretory cargo trafficking. Zhang Z, et al. Sci Adv, 2020 Feb. PMID 32095531, Free PMC Article
    2. The conserved transmembrane protein TMEM-39 coordinates with COPII to promote collagen secretion and regulate ER stress response. Zhang Z, et al. PLoS Genet, 2021 Feb. PMID 33524011, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Peptidase M12B domain-containing protein
    NP_508681.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      3931650..3937897
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076280.6 → NP_508681.3  Peptidase M12B domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508681.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5A4YQ91
      Conserved Domains (4) summary
      smart00209
      Location:836 → 881
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:201 → 416
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam17771
      Location:434 → 502
      ADAM_CR_2; ADAM cysteine-rich domain
      cl15278
      Location:699 → 751
      TSP_1; Thrombospondin type 1 domain
    Nucleotide Protein
    Heading Accession and Version

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