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    ketn-1 Kettin homolog [ Caenorhabditis elegans ]

    Gene ID: 178740, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ketn-1
    Official Full Name
    Kettin homolog
    Primary source
    WormBase:WBGene00004130
    Locus tag
    CELE_F54E2.3
    See related
    AllianceGenome:WB:WBGene00004130
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable actin binding activity. Located in I band. Is expressed in body wall musculature; muscle cell; pharynx; and reproductive system. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ketn-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    29
    Sequence:
    Chromosome: V; NC_003283.11 (2781939..2807860, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class J Neighboring gene pseudo Neighboring gene Lipoprotein Neighboring gene ncRNA Neighboring gene WAP domain-containing protein Neighboring gene ncRNA Neighboring gene CUB_2 domain-containing protein Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Kettin, the large actin-binding protein with multiple immunoglobulin domains, is essential for sarcomeric actin assembly and larval development in Caenorhabditis elegans. Ono K, et al. FEBS J, 2020 Feb. PMID 31411810, Free PMC Article
    2. Molecular and biochemical characterization of kettin in Caenorhabditis elegans. Ono S, et al. J Muscle Res Cell Motil, 2005. PMID 16453162
    3. Sequence and expression of the kettin gene in Drosophila melanogaster and Caenorhabditis elegans. Kolmerer B, et al. J Mol Biol, 2000 Feb 18. PMID 10669599
    4. Caenorhabditis elegans kettin, a large immunoglobulin-like repeat protein, binds to filamentous actin and provides mechanical stability to the contractile apparatuses in body wall muscle. Ono K, et al. Mol Biol Cell, 2006 Jun. PMID 16597697, Free PMC Article
    5. The ALP-Enigma protein ALP-1 functions in actin filament organization to promote muscle structural integrity in Caenorhabditis elegans. Han HF, et al. Mol Biol Cell, 2009 May. PMID 19261811, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Kettin, the large actin-binding protein with multiple immunoglobulin domains, is essential for sarcomeric actin assembly and larval development in Caenorhabditis elegans.
      Title: Kettin, the large actin-binding protein with multiple immunoglobulin domains, is essential for sarcomeric actin assembly and larval development in Caenorhabditis elegans.
    2. Kettin is an important regulator of myofibrillar organization and provides mechanical stability to the myofibrils during contraction.
      Title: Caenorhabditis elegans kettin, a large immunoglobulin-like repeat protein, binds to filamentous actin and provides mechanical stability to the contractile apparatuses in body wall muscle.
    3. In Caenorhabditis elegans, the kettin gene is independent of the genes for other connectin/titin-related proteins. Immunofluorescent localization of kettin shows that it localizes to the I-bands in the obliquely striated body wall muscle.
      Title: Molecular and biochemical characterization of kettin in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in I band IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sarcomere IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Kettin homolog
    NP_001294666.1
    • Confirmed by transcript evidence
    NP_001294667.1
    • Confirmed by transcript evidence
    NP_001294668.1
    • Confirmed by transcript evidence
    NP_001294669.1
    • Confirmed by transcript evidence
    NP_001303736.1
    • Confirmed by transcript evidence
    NP_001303737.1
    • Confirmed by transcript evidence
    NP_001364781.1
    • Confirmed by transcript evidence
    NP_001364782.1
    • Confirmed by transcript evidence
    NP_001364783.1
    • Confirmed by transcript evidence
    NP_001364827.1
    • Confirmed by transcript evidence
    NP_001364828.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      2781939..2807860 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001307737.5 → NP_001294666.1  Kettin homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294666.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CLU0
      Conserved Domains (7) summary
      cd00096
      Location:3602 → 3673
      Ig; Immunoglobulin domain
      smart00408
      Location:2140 → 2208
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:3327 → 3406
      IG; Immunoglobulin
      smart00410
      Location:2799 → 2878
      IG_like; Immunoglobulin like
      pfam07679
      Location:4571 → 4660
      I-set; Immunoglobulin I-set domain
      pfam06582
      Location:2357 → 2382
      DUF1136; Repeat of unknown function (DUF1136)
      cl11960
      Location:4801 → 4886
      Ig; Immunoglobulin domain

    2. NM_001377593.1 → NP_001364783.1  Kettin homolog [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (3) summary
      pfam06582
      Location:1718 → 1743
      DUF1136; Repeat of unknown function (DUF1136)
      pfam07679
      Location:3932 → 4021
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:551 → 642
      Ig; Immunoglobulin domain

    3. NM_001377592.1 → NP_001364782.1  Kettin homolog [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (3) summary
      pfam07679
      Location:3932 → 4021
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:3949 → 3953
      Ig; Ig strand B [structural motif]
      cl11960
      Location:551 → 642
      Ig; Immunoglobulin domain

    4. NM_001307738.4 → NP_001294667.1  Kettin homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294667.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CLT3
      Conserved Domains (3) summary
      pfam07679
      Location:4530 → 4619
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:4547 → 4551
      Ig; Ig strand B [structural motif]
      cl11960
      Location:1190 → 1281
      Ig; Immunoglobulin domain

    5. NM_001307740.4 → NP_001294669.1  Kettin homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294669.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CJB8
      Conserved Domains (3) summary
      pfam07679
      Location:4604 → 4693
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:4621 → 4625
      Ig; Ig strand B [structural motif]
      cl11960
      Location:1190 → 1281
      Ig; Immunoglobulin domain

    6. NM_001307739.4 → NP_001294668.1  Kettin homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294668.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0M7RDU5, A0A0M9JJ85, H2L074, H2L075, H2L076, Q5PY59, Q8MXD8, Q9NL87, V6CJB8, V6CKH1, V6CLP5, V6CLT3, V6CLU0, V6CLU5
      Conserved Domains (3) summary
      pfam07679
      Location:4645 → 4734
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:4662 → 4666
      Ig; Ig strand B [structural motif]
      cl11960
      Location:1190 → 1281
      Ig; Immunoglobulin domain

    7. NM_001377590.2 → NP_001364781.1  Kettin homolog [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (3) summary
      pfam07679
      Location:3891 → 3980
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:3908 → 3912
      Ig; Ig strand B [structural motif]
      cl11960
      Location:551 → 642
      Ig; Immunoglobulin domain

    8. NM_001377591.2 → NP_001364828.1  Kettin homolog [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (3) summary
      pfam07679
      Location:3965 → 4054
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:3982 → 3986
      Ig; Ig strand B [structural motif]
      cl11960
      Location:551 → 642
      Ig; Immunoglobulin domain

    9. NM_001377594.2 → NP_001364827.1  Kettin homolog [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (3) summary
      pfam07679
      Location:4006 → 4095
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:4023 → 4027
      Ig; Ig strand B [structural motif]
      cl11960
      Location:551 → 642
      Ig; Immunoglobulin domain

    10. NM_001316807.3 → NP_001303736.1  Kettin homolog [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0M7RDU5
      Conserved Domains (6) summary
      cd00096
      Location:2110 → 2181
      Ig; Immunoglobulin domain
      smart00408
      Location:648 → 716
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:1307 → 1386
      IG_like; Immunoglobulin like
      pfam07679
      Location:3079 → 3168
      I-set; Immunoglobulin I-set domain
      pfam06582
      Location:865 → 890
      DUF1136; Repeat of unknown function (DUF1136)
      cl11960
      Location:3309 → 3394
      Ig; Immunoglobulin domain

    11. NM_001316808.3 → NP_001303737.1  Kettin homolog [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0M9JJ85
      Conserved Domains (6) summary
      cd00096
      Location:1973 → 2044
      Ig; Immunoglobulin domain
      smart00408
      Location:511 → 579
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:1170 → 1249
      IG_like; Immunoglobulin like
      pfam07679
      Location:2942 → 3031
      I-set; Immunoglobulin I-set domain
      pfam06582
      Location:728 → 753
      DUF1136; Repeat of unknown function (DUF1136)
      cl11960
      Location:3172 → 3257
      Ig; Immunoglobulin domain
    Nucleotide Protein
    Heading Accession and Version

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