U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    frm-4 FERM domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172189, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    frm-4
    Official Full Name
    FERM domain-containing protein
    Primary source
    WormBase:WBGene00001491
    Locus tag
    CELE_C24A11.8
    See related
    AllianceGenome:WB:WBGene00001491
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in actomyosin structure organization. Predicted to be located in membrane. Predicted to be active in cytoskeleton. Is expressed in several structures, including hypodermis; intestine; nervous system; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with eye movement abnormalities and ataxia. Orthologous to human FRMD3 (FERM domain containing 3) and FRMD5 (FERM domain containing 5). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See frm-4 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    19
    Sequence:
    Chromosome: I; NC_003279.8 (5402884..5412400, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene polynucleotide adenylyltransferase Neighboring gene ncRNA Neighboring gene RING-type domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Decaprenyl-diphosphate synthase subunit 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The microRNA miR-1 regulates a MEF-2-dependent retrograde signal at neuromuscular junctions. Simon DJ, et al. Cell, 2008 May 30. PMID 18510933, Free PMC Article
    2. The C. elegans ezrin-radixin-moesin protein ERM-1 is necessary for apical junction remodelling and tubulogenesis in the intestine. Van Fürden D, et al. Dev Biol, 2004 Aug 1. PMID 15242805
    3. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
    4. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
    5. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in actomyosin structure organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    FERM domain-containing protein
    NP_001249887.1
    • Confirmed by transcript evidence
    NP_001370485.1
    • Confirmed by transcript evidence
    NP_491586.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      5402884..5412400 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001262958.3 → NP_001249887.1  FERM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001249887.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KYZ7
      Conserved Domains (2) summary
      smart00295
      Location:29 → 226
      B41; Band 4.1 homologues
      cl17171
      Location:212 → 346
      PH-like; Pleckstrin homology-like domain

    2. NM_001383090.2 → NP_001370485.1  FERM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95Q79
      Conserved Domains (2) summary
      smart00295
      Location:29 → 226
      B41; Band 4.1 homologues
      cl17171
      Location:212 → 346
      PH-like; Pleckstrin homology-like domain

    3. NM_059185.8 → NP_491586.1  FERM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491586.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KYZ6
      Conserved Domains (2) summary
      smart00295
      Location:29 → 218
      B41; Band 4.1 homologues
      cl17171
      Location:204 → 338
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools