mlck-1 Protein kinase domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mlck-1
Official Full Name: Protein kinase domain-containing protein
Primary source: WormBase:WBGene00013869
Locus tag: CELE_ZC373.4
See related: AllianceGenome:WB:WBGene00013869
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable myosin light chain kinase activity. Predicted to be involved in signal transduction. Predicted to be active in cytoplasm. Is expressed in anal sphincter muscle; hermaphrodite gonad; pharynx; and vulval cell. Orthologous to human MYLK4 (myosin light chain kinase family member 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mlck-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 22

Sequence:: Chromosome: X; NC_003284.9 (10062451..10069792, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the Caenorhabditis elegans myosin light-chain kinase, MLCK-1, required for contraction of spermathecae, was identified.
Title: The myosin light-chain kinase MLCK-1 relocalizes during Caenorhabditis elegans ovulation to promote actomyosin bundle assembly and drive contraction.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZC373.4 (e-PCR)
- UniSTS:308209

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables myosin light chain kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Protein kinase domain-containing protein

NP_509689.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

10062451..10069792 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_077288.7 → NP_509689.1 Protein kinase domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509689.1

Status: REVIEWED

UniProtKB/TrEMBL

Q23260

Conserved Domains (1) summary

cl21453
Location:51 → 300

PKc_like; Protein Kinases, catalytic domain