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    aipr-1 TPR_REGION domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 174092, updated on 9-Dec-2024

    Summary

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    Official Symbol
    aipr-1
    Official Full Name
    TPR_REGION domain-containing protein
    Primary source
    WormBase:WBGene00016966
    Locus tag
    CELE_C56C10.10
    See related
    AllianceGenome:WB:WBGene00016966
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Is expressed in several structures, including amphid sheath cell; dorsal nerve cord; neurons; oocyte; and spermatheca. Human ortholog(s) of this gene implicated in Leber congenital amaurosis; Leber congenital amaurosis 4; blindness; pituitary adenoma 1; and retinitis pigmentosa. Orthologous to several human genes including AIP (aryl hydrocarbon receptor interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See aipr-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    6
    Sequence:
    Chromosome: II; NC_003280.10 (6592440..6594251, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Charged multivesicular body protein 4b Neighboring gene 45 kDa calcium-binding protein Neighboring gene DnaJ homolog subfamily C member 16;Thioredoxin domain-containing protein Neighboring gene Ectopic P granules protein 5 Neighboring gene Vacuolar protein sorting-associated protein 33B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AIP limits neurotransmitter release by inhibiting calcium bursts from the ryanodine receptor. Chen B, et al. Nat Commun, 2017 Nov 9. PMID 29123133, Free PMC Article
    2. Hsp90 in non-mammalian metazoan model systems. Haslbeck V, et al. Biochim Biophys Acta, 2012 Mar. PMID 21983200
    3. Rapid and Efficient Identification of Caenorhabditis elegans Legacy Mutations Using Hawaiian SNP-Based Mapping and Whole-Genome Sequencing. Jaramillo-Lambert A, et al. G3 (Bethesda), 2015 Mar 4. PMID 25740937, Free PMC Article
    4. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AIPR-1 is a potent inhibitor of synaptic transmission.AIPR-1 is a critical regulator of neurotransmitter release.
      Title: AIP limits neurotransmitter release by inhibiting calcium bursts from the ryanodine receptor.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    TPR_REGION domain-containing protein
    NP_495339.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      6592440..6594251 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062938.6 → NP_495339.1  TPR_REGION domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495339.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18888
      Conserved Domains (3) summary
      sd00006
      Location:191 → 237
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:191 → 218
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:192 → 271
      TPR_11; TPR repeat
    Nucleotide Protein
    Heading Accession and Version

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