nuo-4 Deoxynucleoside kinase domain-containing protein;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nuo-4
Official Full Name: Deoxynucleoside kinase domain-containing protein;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
Primary source: WormBase:WBGene00019401
Locus tag: CELE_K04G7.4
See related: AllianceGenome:WB:WBGene00019401
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable kinase activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Predicted to be located in mitochondrial matrix. Predicted to be part of respiratory chain complex I. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 22. Orthologous to human NDUFA10 (NADH:ubiquinone oxidoreductase subunit A10). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See nuo-4 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 7

Sequence:: Chromosome: III; NC_003281.10 (7156026..7158809, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K04G7.4 (e-PCR)
- UniSTS:311414

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in deoxyribonucleoside monophosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial electron transport, NADH to ubiquinone	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial electron transport, NADH to ubiquinone	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
part_of respiratory chain complex	IEA Inferred from Electronic Annotation more info
part_of respiratory chain complex I	IBA Inferred from Biological aspect of Ancestor more info
part_of respiratory chain complex I	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Deoxynucleoside kinase domain-containing protein;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

NP_001379562.1

Partially confirmed by transcript evidence

NP_741215.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

7156026..7158809 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_171184.5 → NP_741215.1 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741215.1

Status: REVIEWED

UniProtKB/TrEMBL

Q21233

Conserved Domains (2) summary

cd02030
Location:74 → 296

NDUO42; NADH:Ubiquinone oxioreductase, 42 kDa (NDUO42) is a family of proteins that are highly similar to deoxyribonucleoside kinases (dNK). Members of this family have been identified as one of the subunits of NADH:Ubiquinone oxioreductase (complex I), a ...

pfam13671
Location:74 → 261

AAA_33; AAA domain
NM_001392136.1 → NP_001379562.1 Deoxynucleoside kinase domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q8MQ11

Conserved Domains (1) summary

cl17190
Location:74 → 128

NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...