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    npp-12 BIG2 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172348, updated on 9-Dec-2024

    Summary

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    Official Symbol
    npp-12
    Official Full Name
    BIG2 domain-containing protein
    Primary source
    WormBase:WBGene00003798
    Locus tag
    CELE_T23H2.1
    See related
    AllianceGenome:WB:WBGene00003798
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Part of nuclear pore. Orthologous to human NUP210 (nucleoporin 210) and NUP210L (nucleoporin 210 like). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See npp-12 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    15
    Sequence:
    Chromosome: I; NC_003279.8 (6447304..6453954)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene C2 domain-containing protein Neighboring gene Transcription termination factor 2 Neighboring gene MAM domain-containing protein Neighboring gene ncRNA Neighboring gene Ras-related protein Rab-10

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nuclear pore protein gp210 is essential for viability in HeLa cells and Caenorhabditis elegans. Cohen M, et al. Mol Biol Cell, 2003 Oct. PMID 14517331, Free PMC Article
    2. A role for gp210 in mitotic nuclear-envelope breakdown. Galy V, et al. J Cell Sci, 2008 Feb 1. PMID 18216332
    3. Lipin is required for efficient breakdown of the nuclear envelope in Caenorhabditis elegans. Gorjánácz M, et al. J Cell Sci, 2009 Jun 15. PMID 19494125
    4. Spatial control of phospholipid flux restricts endoplasmic reticulum sheet formation to allow nuclear envelope breakdown. Bahmanyar S, et al. Genes Dev, 2014 Jan 15. PMID 24449268, Free PMC Article
    5. Mechanisms of nuclear pore complex disassembly by the mitotic Polo-like kinase 1 (PLK-1) in C. elegans embryos. Nkombo Nkoula S, et al. Sci Adv, 2023 Jul 21. PMID 37467327, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear pore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    BIG2 domain-containing protein
    NP_491855.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6447304..6453954
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059454.5 → NP_491855.1  BIG2 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491855.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      P91495
      Conserved Domains (1) summary
      pfam02368
      Location:438 → 513
      Big_2; Bacterial Ig-like domain (group 2)
    Nucleotide Protein
    Heading Accession and Version

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