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    M176.9 Tyrosine-protein kinase [ Caenorhabditis elegans ]

    Gene ID: 13186458, updated on 9-Dec-2024

    Summary

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    Official Symbol
    M176.9
    Official Full Name
    Tyrosine-protein kinase
    Primary source
    WormBase:WBGene00014813
    Locus tag
    CELE_M176.9
    See related
    AllianceGenome:WB:WBGene00014813
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein tyrosine kinase activity. Predicted to be involved in protein phosphorylation. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in esophagus squamous cell carcinoma; hepatocellular carcinoma; and lung adenocarcinoma. Orthologous to human FER (FER tyrosine kinase) and FES (FES proto-oncogene, tyrosine kinase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See M176.9 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    8
    Sequence:
    Chromosome: II; NC_003280.10 (9409301..9411597, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Arrestin C-terminal-like domain-containing protein Neighboring gene Arrestin C-terminal-like domain-containing protein Neighboring gene ncRNA Neighboring gene Glutathione synthetase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Tyrosine-protein kinase
    NP_001305207.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      9409301..9411597 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001318278.3 → NP_001305207.1  Tyrosine-protein kinase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0S4FT70
      Conserved Domains (3) summary
      smart00219
      Location:239 → 484
      TyrKc; Tyrosine kinase, catalytic domain
      cd10361
      Location:116 → 212
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cd00192
      Location:243 → 493
      PTKc; Catalytic domain of Protein Tyrosine Kinases

    RNA

    1. NR_145829.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

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    Research Materials