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    pmr-1 Calcium-transporting ATPase [ Caenorhabditis elegans ]

    Gene ID: 173176, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pmr-1
    Official Full Name
    Calcium-transporting ATPase
    Primary source
    WormBase:WBGene00004063
    Locus tag
    CELE_ZK256.1
    See related
    AllianceGenome:WB:WBGene00004063
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables P-type calcium transporter activity and P-type manganese transporter activity. Involved in several processes, including metal ion transport; response to calcium ion; and response to manganese ion. Located in Golgi apparatus and membrane. Is expressed in gonad; intestine; nervous system; pharyngeal-intestinal valve; and seam cell. Human ortholog(s) of this gene implicated in Hailey-Hailey disease. Orthologous to human ATP2C1 (ATPase secretory pathway Ca2+ transporting 1) and ATP2C2 (ATPase secretory pathway Ca2+ transporting 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pmr-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    13
    Sequence:
    Chromosome: I; NC_003279.8 (13004437..13023592)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Neuropeptide-Like Protein Neighboring gene Smu-1 suppressor of mec-8 and unc-52 protein Neighboring gene Uncharacterized protein Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene Nuclear hormone receptor family member nhr-85

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Golgi PMR1 P-type ATPase of Caenorhabditis elegans. Identification of the gene and demonstration of calcium and manganese transport. Van Baelen K, et al. J Biol Chem, 2001 Apr 6. PMID 11134055
    2. Baseline cytosolic Ca2+ oscillations derived from a non-endoplasmic reticulum Ca2+ store. Missiaen L, et al. J Biol Chem, 2001 Oct 19. PMID 11514551
    3. The secretory pathway calcium ATPase PMR-1/SPCA1 has essential roles in cell migration during Caenorhabditis elegans embryonic development. Praitis V, et al. PLoS Genet, 2013 May. PMID 23696750, Free PMC Article
    4. The slo-1 BK potassium channel interacts genetically with pmr-1 secretory pathway calcium ATPase during C. elegans embryonic cell migration. Thurman M, et al. MicroPubl Biol, 2021 Jan 14. PMID 33474530, Free PMC Article
    5. The Ca2+/Mn2+ ion-pump PMR1 links elevation of cytosolic Ca(2+) levels to α-synuclein toxicity in Parkinson's disease models. Büttner S, et al. Cell Death Differ, 2013 Mar. PMID 23154387, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We provide genetic evidence that pmr-1 interfered nematodes mounted a stronger innate immune response to Gram-positive bacterial infection.
      Title: Pmr-1 gene affects susceptibility of Caenorhabditis elegans to Staphylococcus aureus infection through glycosylation and stress response pathways' alterations.
    2. Gene interaction experiments show changing the activity of itr-1/IP3R and unc-68/RyR modulates levels of embryonic lethality in Pmr-1 strains, indicating pmr-1 acts with these calcium channels to regulate cell migration
      Title: The secretory pathway calcium ATPase PMR-1/SPCA1 has essential roles in cell migration during Caenorhabditis elegans embryonic development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type calcium transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables P-type calcium transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables P-type calcium transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type manganese transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables P-type manganese transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in manganese ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in manganese ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in manganese ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to calcium ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to manganese ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sarcoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Calcium-transporting ATPase
    NP_001021862.1
    • Confirmed by transcript evidence
    NP_001359606.1
    • Confirmed by transcript evidence
    NP_001366903.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      13004437..13023592
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001373648.4 → NP_001359606.1  Calcium-transporting ATPase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFK9
      Conserved Domains (1) summary
      cd02085
      Location:38 → 882
      P-type_ATPase_SPCA; golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p

    2. NM_001026691.5 → NP_001021862.1  Calcium-transporting ATPase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021862.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EDU1
      Conserved Domains (6) summary
      cd01427
      Location:610 → 723
      HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...
      TIGR01522
      Location:81 → 967
      ATPase-IIA2_Ca; golgi membrane calcium-translocating P-type ATPase
      pfam00122
      Location:181 → 402
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:790 → 961
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:98 → 155
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam13246
      Location:474 → 554
      Cation_ATPase; Cation transport ATPase (P-type)

    3. NM_001381237.1 → NP_001366903.1  Calcium-transporting ATPase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EC26
      Conserved Domains (1) summary
      cl21460
      Location:38 → 694
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    Nucleotide Protein
    Heading Accession and Version

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