U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ncs-1 Neuronal calcium sensor 1 [ Caenorhabditis elegans ]

    Gene ID: 180448, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ncs-1
    Official Full Name
    Neuronal calcium sensor 1
    Primary source
    WormBase:WBGene00003563
    Locus tag
    CELE_C44C1.3
    See related
    AllianceGenome:WB:WBGene00003563
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable calcium ion binding activity and calcium sensitive guanylate cyclase activator activity. Involved in chemosensory behavior; chemotaxis; and response to alkaline pH. Located in neuronal cell body. Is expressed in head neurons; pm1; and tail neurons. Orthologous to human NCS1 (neuronal calcium sensor 1). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ncs-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    6
    Sequence:
    Chromosome: X; NC_003284.9 (960452..963271, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Beta-arrestin arr-1 Neighboring gene AP-3 complex subunit mu Neighboring gene Chitinase domain-containing protein 1 Neighboring gene Neuropeptide-Like Protein Neighboring gene Vacuolar protein sorting-associated protein 45 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Sense and specificity in neuronal calcium signalling. Burgoyne RD, et al. Biochim Biophys Acta, 2015 Sep. PMID 25447549, Free PMC Article
    2. Identification of key structural elements for neuronal calcium sensor-1 function in the regulation of the temperature-dependency of locomotion in C. elegans. Martin VM, et al. Mol Brain, 2013 Aug 27. PMID 23981466, Free PMC Article
    3. Evaluation of the long-term memory for thermosensation regulated by neuronal calcium sensor-1 in Caenorhabditis elegans. Ye HY, et al. Neurosci Bull, 2008 Feb. PMID 18273069, Free PMC Article
    4. Trace administration of vitamin E can retrieve and prevent UV-irradiation- and metal exposure-induced memory deficits in nematode Caenorhabditis elegans. Ye H, et al. Neurobiol Learn Mem, 2008 Jul. PMID 18191592
    5. Ca2+ signaling via the neuronal calcium sensor-1 regulates associative learning and memory in C. elegans. Gomez M, et al. Neuron, 2001 Apr. PMID 11343658

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The current work has allowed physiological assessment of suggestions from structural studies on the key structural features that underlie the interaction of NCS-1 with its target proteins.
      Title: Identification of key structural elements for neuronal calcium sensor-1 function in the regulation of the temperature-dependency of locomotion in C. elegans.
    2. These findings suggest that ARF-1.1 interacts with NCS-1 in AIY neurons and potentially pifk-1 in the Ca(2+) signaling pathway that leads to inhibited locomotion at an elevated temperature.
      Title: Interaction of ARF-1.1 and neuronal calcium sensor-1 in the control of the temperature-dependency of locomotion in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium sensitive guanylate cyclase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chemosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to alkaline pH IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Neuronal calcium sensor 1
    NP_508186.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      960452..963271 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_075785.4 → NP_508186.1  Neuronal calcium sensor 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508186.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P36608, Q18608
      Conserved Domains (2) summary
      COG5126
      Location:11 → 179
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00051
      Location:100 → 174
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36608.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools