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    egl-10 Regulator of G-protein signaling egl-10 [ Caenorhabditis elegans ]

    Gene ID: 179707, updated on 9-Dec-2024

    Summary

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    Official Symbol
    egl-10
    Official Full Name
    Regulator of G-protein signaling egl-10
    Primary source
    WormBase:WBGene00001179
    Locus tag
    CELE_F28C1.2
    See related
    AllianceGenome:WB:WBGene00001179
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTPase activator activity. Involved in several processes, including G protein-coupled dopamine receptor signaling pathway; regulation of egg-laying behavior; and rhythmic behavior. Located in cytoplasm and neuron projection. Is expressed in body wall musculature and neurons. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human RGS6 (regulator of G protein signaling 6) and RGS7 (regulator of G protein signaling 7). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See egl-10 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    11
    Sequence:
    Chromosome: V; NC_003283.11 (12453290..12463008, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene BPTI/Kunitz inhibitor domain-containing protein Neighboring gene ncRNA Neighboring gene Suppressor of white apricot N-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulating G protein signaling. Roush W. Science, 1996 Feb 23. PMID 8599078
    2. Serotonergic chemosensory neurons modify the C. elegans immune response by regulating G-protein signaling in epithelial cells. Anderson A, et al. PLoS Pathog, 2013. PMID 24348250, Free PMC Article
    3. Metabolism of 5-HT in the nematode Caenorhabditis elegans: identification of a 5-HT N-acetyltransferase that is developmentally regulated. Muimo R, et al. Biochem Soc Trans, 1993 Aug. PMID 8224443
    4. Two RGS proteins that inhibit Galpha(o) and Galpha(q) signaling in C. elegans neurons require a Gbeta(5)-like subunit for function. Chase DL, et al. Curr Biol, 2001 Feb 20. PMID 11250150
    5. An N-terminal region of Caenorhabditis elegans RGS proteins EGL-10 and EAT-16 directs inhibition of G(alpha)o versus G(alpha)q signaling. Patikoglou GA, et al. J Biol Chem, 2002 Dec 6. PMID 12354761

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled dopamine receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of G protein-coupled receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rhythmic behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Regulator of G-protein signaling egl-10
    NP_001256418.1
    • Confirmed by transcript evidence
    NP_001256419.1
    • Partially confirmed by transcript evidence
    NP_001256420.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      12453290..12463008 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269489.4 → NP_001256418.1  Regulator of G-protein signaling egl-10 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256418.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F5GUD0
      Conserved Domains (3) summary
      smart00224
      Location:334 → 395
      GGL; G protein gamma subunit-like motifs
      cd08705
      Location:414 → 535
      RGS_R7-like; Regulator of G protein signaling (RGS) domain found in the R7 subfamily of proteins
      cd04450
      Location:29 → 116
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

    2. NM_001269491.2 → NP_001256420.1  Regulator of G-protein signaling egl-10 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256420.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P49809, Q19855
      Conserved Domains (3) summary
      smart00224
      Location:334 → 395
      GGL; G protein gamma subunit-like motifs
      cd08705
      Location:414 → 535
      RGS_R7-like; Regulator of G protein signaling (RGS) domain found in the R7 subfamily of proteins
      cd04450
      Location:29 → 116
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

    3. NM_001269490.3 → NP_001256419.1  Regulator of G-protein signaling egl-10 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256419.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F5GUC9
      Conserved Domains (3) summary
      smart00224
      Location:334 → 395
      GGL; G protein gamma subunit-like motifs
      cd08705
      Location:414 → 535
      RGS_R7-like; Regulator of G protein signaling (RGS) domain found in the R7 subfamily of proteins
      cd04450
      Location:29 → 116
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49809.1

    Gene LinkOut

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