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    sid-3 Tyrosine-protein kinase sid-3 [ Caenorhabditis elegans ]

    Gene ID: 181756, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sid-3
    Official Full Name
    Tyrosine-protein kinase sid-3
    Primary source
    WormBase:WBGene00002207
    Locus tag
    CELE_B0302.1
    See related
    AllianceGenome:WB:WBGene00002207
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Involved in regulatory ncRNA-mediated post-transcriptional gene silencing. Located in cytoplasm. Is expressed in several structures, including excretory canal; intestine; phasmid neurons; rectal gland cell; and somatic cell. Orthologous to several human genes including TNK2 (tyrosine kinase non receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sid-3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    15
    Sequence:
    Chromosome: X; NC_003284.9 (17186380..17193292)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Integrated regulation of dopaminergic and epigenetic effectors of neuroprotection in Parkinson's disease models. Nourse JB Jr, et al. Proc Natl Acad Sci U S A, 2023 Feb 14. PMID 36745808, Free PMC Article
    2. Natural Viruses of Caenorhabditis Nematodes. Félix MA, et al. Annu Rev Genet, 2019 Dec 3. PMID 31424970
    3. Conserved tyrosine kinase promotes the import of silencing RNA into Caenorhabditis elegans cells. Jose AM, et al. Proc Natl Acad Sci U S A, 2012 Sep 4. PMID 22912399, Free PMC Article
    4. An Alternative STAT Signaling Pathway Acts in Viral Immunity in Caenorhabditis elegans. Tanguy M, et al. mBio, 2017 Sep 5. PMID 28874466, Free PMC Article
    5. An Evolutionarily Conserved Pathway Essential for Orsay Virus Infection of Caenorhabditis elegans. Jiang H, et al. mBio, 2017 Sep 5. PMID 28874467, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Repression of CDC-42 or SID-3 suppressed trafficking process that requires actin assembly and disassembly.
      Title: Actin organization and endocytic trafficking are controlled by a network linking NIMA-related kinases to the CDC-42-SID-3/ACK1 pathway.
    2. Systemic RNAi defective-3 (SID-3) is a conserved tyrosine kinase required for the efficient import of dsRNA.
      Title: Conserved tyrosine kinase promotes the import of silencing RNA into Caenorhabditis elegans cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulatory ncRNA-mediated gene silencing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Tyrosine-protein kinase sid-3
    NP_510783.2
    • Confirmed by transcript evidence
    NP_510784.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      17186380..17193292
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078383.7 → NP_510784.2  Tyrosine-protein kinase sid-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510784.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q10925
      Conserved Domains (4) summary
      cd09539
      Location:9 → 70
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      smart00221
      Location:107 → 363
      STYKc; Protein kinase; unclassified specificity
      smart00326
      Location:371 → 421
      SH3; Src homology 3 domains
      cd05040
      Location:111 → 365
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

    2. NM_078382.7 → NP_510783.2  Tyrosine-protein kinase sid-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510783.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q10925, Q7JP57, Q7JP58, Q7JP59, Q95ZZ7
      Conserved Domains (4) summary
      cd09539
      Location:9 → 70
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      smart00221
      Location:107 → 363
      STYKc; Protein kinase; unclassified specificity
      smart00326
      Location:371 → 421
      SH3; Src homology 3 domains
      cd05040
      Location:111 → 365
      PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase

    RNA

    1. NR_136346.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q10925.2

    Gene LinkOut

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    Chemical Information
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