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    Y42A5A.1 Aminopeptidase [ Caenorhabditis elegans ]

    Gene ID: 179536, updated on 9-Dec-2024

    Summary

    Official Symbol
    Y42A5A.1
    Official Full Name
    Aminopeptidase
    Primary source
    WormBase:WBGene00012776
    Locus tag
    CELE_Y42A5A.1
    See related
    AllianceGenome:WB:WBGene00012776
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in peptide catabolic process and proteolysis. Predicted to be active in cytoplasm; extracellular space; and membrane. Orthologous to human TRHDE (thyrotropin releasing hormone degrading enzyme). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See Y42A5A.1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    19
    Sequence:
    Chromosome: V; NC_003283.11 (11087948..11097985)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Beta-lactamase-related domain-containing protein Neighboring gene ncRNA Neighboring gene FMRF-Like Peptide Neighboring gene ncRNA Neighboring gene Cyclin-dependent kinase-like 1;Protein kinase domain-containing protein Neighboring gene LYR motif-containing protein 5 Neighboring gene pseudo

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloaminopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in peptide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Aminopeptidase
    NP_505820.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      11087948..11097985
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073419.6NP_505820.1  Aminopeptidase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505820.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U2H2
      Conserved Domains (3) summary
      cd09601
      Location:181623
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:159549
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:688998
      ERAP1_C; ERAP1-like C-terminal domain