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    acs-1 Medium-chain acyl-CoA ligase ACSF2, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 179043, updated on 9-Dec-2024

    Summary

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    Official Symbol
    acs-1
    Official Full Name
    Medium-chain acyl-CoA ligase ACSF2, mitochondrial
    Primary source
    WormBase:WBGene00018488
    Locus tag
    CELE_F46E10.1
    See related
    AllianceGenome:WB:WBGene00018488
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable medium-chain fatty acid-CoA ligase activity. Involved in establishment or maintenance of epithelial cell apical/basal polarity. Is expressed in gonad; intestine; neurons; and seam cell. Orthologous to human ACSF2 (acyl-CoA synthetase family member 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See acs-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    9
    Sequence:
    Chromosome: V; NC_003283.11 (6524989..6532089)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Glycine-rich cell wall structural protein Neighboring gene KilA-N domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene CC domain-containing protein Neighboring gene F-box domain-containing protein;F-box protein dre-1 Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. mmBCFA C17iso ensures endoplasmic reticulum integrity for lipid droplet growth. Zhang J, et al. J Cell Biol, 2021 Nov 1. PMID 34623380, Free PMC Article
    2. Regulation of maternal phospholipid composition and IP(3)-dependent embryonic membrane dynamics by a specific fatty acid metabolic event in C. elegans. Kniazeva M, et al. Genes Dev, 2012 Mar 15. PMID 22426533, Free PMC Article
    3. Multiple checkpoints of protein clearance machinery are modulated by a common microRNA, miR-4813-3p, through its putative target genes: Studies employing transgenic C. elegans model. Sarkar A, et al. Biochim Biophys Acta Mol Cell Res, 2022 Dec. PMID 35998789
    4. Regulation of fat storage and reproduction by Krüppel-like transcription factor KLF3 and fat-associated genes in Caenorhabditis elegans. Zhang J, et al. J Mol Biol, 2011 Aug 19. PMID 21704635, Free PMC Article
    5. A branched-chain fatty acid is involved in post-embryonic growth control in parallel to the insulin receptor pathway and its biosynthesis is feedback-regulated in C. elegans. Kniazeva M, et al. Genes Dev, 2008 Aug 1. PMID 18676815, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. C17ISO and ACS-1 functions are necessary for optimal IP(3) signaling essential for early embryogenesis.
      Title: Regulation of maternal phospholipid composition and IP(3)-dependent embryonic membrane dynamics by a specific fatty acid metabolic event in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables medium-chain fatty acid-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in establishment or maintenance of epithelial cell apical/basal polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Medium-chain acyl-CoA ligase ACSF2, mitochondrial
    NP_001023937.1
    • Confirmed by transcript evidence
    NP_001023938.1
    • Confirmed by transcript evidence
    NP_001379958.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      6524989..6532089
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001028766.5 → NP_001023937.1  Medium-chain acyl-CoA ligase ACSF2, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023937.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9UAV8
      Conserved Domains (2) summary
      cd05917
      Location:252 → 604
      FACL_like_2; Uncharacterized subfamily of fatty acid CoA ligase (FACL)
      PRK08315
      Location:53 → 615
      PRK08315; AMP-binding domain protein; Validated

    2. NM_001028767.8 → NP_001023938.1  Medium-chain acyl-CoA ligase ACSF2, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023938.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5TKA4
      Conserved Domains (2) summary
      cd05917
      Location:226 → 578
      FACL_like_2; Uncharacterized subfamily of fatty acid CoA ligase (FACL)
      PRK08315
      Location:27 → 589
      PRK08315; AMP-binding domain protein; Validated

    3. NM_001392534.1 → NP_001379958.1  Medium-chain acyl-CoA ligase ACSF2, mitochondrial [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5TKA3
      Conserved Domains (1) summary
      PRK08315
      Location:8 → 570
      PRK08315; AMP-binding domain protein; Validated
    Nucleotide Protein
    Heading Accession and Version

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