acs-3 Long-chain-fatty-acid--CoA ligase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: acs-3
Official Full Name: Long-chain-fatty-acid--CoA ligase
Primary source: WormBase:WBGene00020343
Locus tag: CELE_T08B1.6
See related: AllianceGenome:WB:WBGene00020343
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable long-chain fatty acid-CoA ligase activity. Predicted to be involved in long-chain fatty acid metabolic process. Predicted to be active in endoplasmic reticulum and membrane. Is expressed in several structures, including excretory cell; intestine; seam cell; tail; and vulva. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See acs-3 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 7

Sequence:: Chromosome: V; NC_003283.11 (1969528..1974514)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ACS-3-derived long-chain fatty acyl-CoAs, perhaps incorporated into complex ligands such as phosphoinositides, modulate NHR-25 function, which in turn regulates an endocrine program of lipid uptake and synthesis.
Title: Regulation of C. elegans fat uptake and storage by acyl-CoA synthase-3 is dependent on NR5A family nuclear hormone receptor nhr-25.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T08B1.6 (e-PCR)
- UniSTS:314935

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acid-CoA ligase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Long-chain-fatty-acid--CoA ligase

NP_503540.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

1969528..1974514

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_071139.7 → NP_503540.1 Long-chain-fatty-acid--CoA ligase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_503540.1

Status: REVIEWED

UniProtKB/TrEMBL

O44560

Conserved Domains (1) summary

cd05927
Location:67 → 648

LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)