U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    cpt-2 Calponin-homology (CH) domain-containing protein;Choline/carnitine acyltransferase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 178025, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    cpt-2
    Official Full Name
    Calponin-homology (CH) domain-containing protein;Choline/carnitine acyltransferase domain-containing protein
    Primary source
    WormBase:WBGene00011122
    Locus tag
    CELE_R07H5.2
    See related
    AllianceGenome:WB:WBGene00011122
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable carnitine O-palmitoyltransferase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to be active in mitochondrion. Is expressed in intestine. Human ortholog(s) of this gene implicated in brain disease; lipid metabolism disorder; and muscular disease. Orthologous to human CPT2 (carnitine palmitoyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See cpt-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    10
    Sequence:
    Chromosome: IV; NC_003282.8 (11179645..11183008)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene RAP homolog (vertebrate Rap GTPase family) Neighboring gene Uncharacterized protein Neighboring gene Peroxisomal membrane protein PEX14 Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 Neighboring gene SKN-1 Dependent Zygotic transcript

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Prowashonupana barley dietary fibre reduces body fat and increases insulin sensitivity in Caenorhabditis elegans model. Gao C, et al. J Funct Foods, 2015 Oct. PMID 27721901, Free PMC Article
    2. Oat consumption reduced intestinal fat deposition and improved health span in Caenorhabditis elegans model. Gao C, et al. Nutr Res, 2015 Sep. PMID 26253816, Free PMC Article
    3. Intracellular lipid surveillance by small G protein geranylgeranylation. Watterson A, et al. Nature, 2022 May. PMID 35585236, Free PMC Article
    4. Evolutionary analysis of the carnitine- and choline acyltransferases suggests distinct evolution of CPT2 versus CPT1 and related variants. van der Hoek MD, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2018 Aug. PMID 29730527
    5. Fatty acid desaturation and the regulation of adiposity in Caenorhabditis elegans. Brock TJ, et al. Genetics, 2007 Jun. PMID 17435249, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carnitine O-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Calponin-homology (CH) domain-containing protein;Choline/carnitine acyltransferase domain-containing protein
    NP_001040977.2
    • Confirmed by transcript evidence
    NP_001040978.2
    • Confirmed by transcript evidence
    NP_001294004.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      11179645..11183008
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001047512.5 → NP_001040977.2  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040977.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECS9
      Conserved Domains (1) summary
      pfam00755
      Location:42 → 639
      Carn_acyltransf; Choline/Carnitine o-acyltransferase

    2. NM_001047513.5 → NP_001040978.2  Calponin-homology (CH) domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040978.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFE6
      Conserved Domains (1) summary
      pfam00755
      Location:16 → 469
      Carn_acyltransf; Choline/Carnitine o-acyltransferase

    3. NM_001307075.3 → NP_001294004.1  Choline/carnitine acyltransferase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294004.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061AL65
      Conserved Domains (1) summary
      pfam00755
      Location:1 → 102
      Carn_acyltransf; Choline/Carnitine o-acyltransferase
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous