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    gcy-4 Receptor-type guanylate cyclase gcy-4 [ Caenorhabditis elegans ]

    Gene ID: 191642, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gcy-4
    Official Full Name
    Receptor-type guanylate cyclase gcy-4
    Primary source
    WormBase:WBGene00001531
    Locus tag
    CELE_ZK970.5
    See related
    AllianceGenome:WB:WBGene00001531
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable guanylate cyclase activity and peptide receptor activity. Involved in chemosensory behavior; chemotaxis; and response to salt. Predicted to be active in plasma membrane. Is expressed in ASER. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gcy-4 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    15
    Sequence:
    Chromosome: II; NC_003280.10 (10304139..10308826, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ATP-dependent Clp protease proteolytic subunit 1, mitochondrial Neighboring gene tRNA-Pro Neighboring gene putative V-type proton ATPase subunit F Neighboring gene ncRNA Neighboring gene tRNA-Pro Neighboring gene tRNA-Pro Neighboring gene ncRNA Neighboring gene Mss4 protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Defining specificity determinants of cGMP mediated gustatory sensory transduction in Caenorhabditis elegans. Smith HK, et al. Genetics, 2013 Aug. PMID 23695300, Free PMC Article
    2. Lateralized gustatory behavior of C. elegans is controlled by specific receptor-type guanylyl cyclases. Ortiz CO, et al. Curr Biol, 2009 Jun 23. PMID 19523832, Free PMC Article
    3. Guanylyl cyclase expression in specific sensory neurons: a new family of chemosensory receptors. Yu S, et al. Proc Natl Acad Sci U S A, 1997 Apr 1. PMID 9096403, Free PMC Article
    4. Receptor-type guanylate cyclase is required for carbon dioxide sensation by Caenorhabditis elegans. Hallem EA, et al. Proc Natl Acad Sci U S A, 2011 Jan 4. PMID 21173231, Free PMC Article
    5. The cloning of a Caenorhabditis elegans guanylyl cyclase and the construction of a ligand-sensitive mammalian/nematode chimeric receptor. Baude EJ, et al. J Biol Chem, 1997 Jun 20. PMID 9188508

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cGMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cGMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chemosensory behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in chemosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chemotaxis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cyclic nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in receptor guanylyl cyclase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to salt IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Receptor-type guanylate cyclase gcy-4
    NP_496218.2
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      10304139..10308826 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063817.2 → NP_496218.2  Receptor-type guanylate cyclase gcy-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496218.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23681
      Conserved Domains (6) summary
      cd06352
      Location:29 → 457
      PBP1_NPR_GC_like; Ligand-binding domain of membrane guanylyl-cyclase receptors
      smart00044
      Location:855 → 1047
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:882 → 1070
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam01094
      Location:49 → 423
      ANF_receptor; Receptor family ligand binding region
      pfam07701
      Location:834 → 876
      HNOBA; Heme NO binding associated
      cl21453
      Location:558 → 819
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q23681.2

    Gene LinkOut

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