cul-5 Cullin-5 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cul-5
Official Full Name: Cullin-5
Primary source: WormBase:WBGene00000840
Locus tag: CELE_ZK856.1
See related: AllianceGenome:WB:WBGene00000840
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable protein-macromolecule adaptor activity and ubiquitin protein ligase binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to be part of Cul5-RING ubiquitin ligase complex and SCF ubiquitin ligase complex. Is expressed in several structures, including hypodermis; intestine; nervous system; tail; and vulval muscle. Orthologous to human CUL5 (cullin 5). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See cul-5 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 15

Sequence:: Chromosome: V; NC_003283.11 (10179535..10183154)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

oocyte maturation from pachytene exit and MPK-1 activation are redundantly controlled by the RBX-2-CUL-5- and RBX-1-CUL-2-based complexes.
Title: C. elegans RBX-2-CUL-5- and RBX-1-CUL-2-based complexes are redundant for oogenesis and activation of the MAP kinase MPK-1.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK856.1 (e-PCR)
- UniSTS:310553

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein-macromolecule adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Cul5-RING ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SCF ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Cullin-5

NP_505616.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

10179535..10183154

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_073215.8 → NP_505616.2 Cullin-5 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_505616.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q23639

Conserved Domains (2) summary

smart00884
Location:692 → 759

Cullin_Nedd8; Cullin protein neddylation domain

pfam00888
Location:7 → 657

Cullin; Cullin family