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    algn-1 Chitobiosyldiphosphodolichol beta-mannosyltransferase [ Caenorhabditis elegans ]

    Gene ID: 175920, updated on 9-Dec-2024

    Summary

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    Official Symbol
    algn-1
    Official Full Name
    Chitobiosyldiphosphodolichol beta-mannosyltransferase
    Primary source
    WormBase:WBGene00020820
    Locus tag
    CELE_T26A5.4
    See related
    AllianceGenome:WB:WBGene00020820
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mannosyltransferase activity. Predicted to be involved in protein glycosylation. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ik. Orthologous to several human genes including ALG1 (ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See algn-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    6
    Sequence:
    Chromosome: III; NC_003281.10 (6460120..6462222)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Histone-lysine N-methyltransferase set-1;SET domain-containing protein Neighboring gene ncRNA Neighboring gene JmjC domain-containing histone demethylation protein 1 Neighboring gene DNA polymerase epsilon subunit 3 Neighboring gene Dynein light chain 1, cytoplasmic Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RNAi screening of human glycogene orthologs in the nematode Caenorhabditis elegans and the construction of the C. elegans glycogene database. Akiyoshi S, et al. Glycobiology, 2015 Jan. PMID 25091817, Free PMC Article
    2. Carbohydrates and glycosylation. Berninsone PM. WormBook, 2006 Dec 18. PMID 18050430, Free PMC Article
    3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Chitobiosyldiphosphodolichol beta-mannosyltransferase
    NP_498420.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      6460120..6462222
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066019.9 → NP_498420.2  Chitobiosyldiphosphodolichol beta-mannosyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498420.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22797
      Conserved Domains (1) summary
      cl10013
      Location:12 → 444
      Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology
    Nucleotide Protein
    Heading Accession and Version

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