U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    nas-4 Metalloendopeptidase;Zinc metalloproteinase nas-4 [ Caenorhabditis elegans ]

    Gene ID: 182259, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    nas-4
    Official Full Name
    Metalloendopeptidase;Zinc metalloproteinase nas-4
    Primary source
    WormBase:WBGene00003523
    Locus tag
    CELE_C05D11.6
    See related
    AllianceGenome:WB:WBGene00003523
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. Is expressed in intestine and pharynx. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See nas-4 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    11
    Sequence:
    Chromosome: III; NC_003281.10 (6411578..6415656, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Protein let-756 Neighboring gene Putative hydroxypyruvate isomerase Neighboring gene PNPLA domain-containing protein;Patatin-like phospholipase domain-containing protein atgl-1 Neighboring gene FHIP family protein C05D11.8

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The astacin protein family in Caenorhabditis elegans. Möhrlen F, et al. Eur J Biochem, 2003 Dec. PMID 14653817
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Metalloendopeptidase;Zinc metalloproteinase nas-4
    NP_001254938.1
    • Confirmed by transcript evidence
    NP_001254939.1
    • Confirmed by transcript evidence
    NP_001370381.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      6411578..6415656 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001382895.1 → NP_001370381.1  Metalloendopeptidase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      D7SFI4
      Conserved Domains (1) summary
      pfam01400
      Location:102 → 290
      Astacin; Astacin (Peptidase family M12A)

    2. NM_001268010.3 → NP_001254939.1  Zinc metalloproteinase nas-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254939.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P55112, Q7Z0N7
      Conserved Domains (2) summary
      cd04280
      Location:106 → 287
      ZnMc_astacin_like; Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to ...
      pfam01400
      Location:102 → 290
      Astacin; Astacin (Peptidase family M12A)

    3. NM_001268009.3 → NP_001254938.1  Metalloendopeptidase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254938.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D7SFI5
      Conserved Domains (2) summary
      cd04280
      Location:106 → 287
      ZnMc_astacin_like; Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to ...
      pfam01400
      Location:102 → 290
      Astacin; Astacin (Peptidase family M12A)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P55112.4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools