cas-1 Adenylyl cyclase-associated protein;C-CAP/cofactor C-like domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cas-1
Official Full Name: Adenylyl cyclase-associated protein;C-CAP/cofactor C-like domain-containing protein
Primary source: WormBase:WBGene00000294
Locus tag: CELE_F41G4.2
See related: AllianceGenome:WB:WBGene00000294
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable actin binding activity and adenylate cyclase binding activity. Predicted to be involved in actin filament organization; cAMP-mediated signaling; and cell morphogenesis. Predicted to be active in cytoplasm. Is expressed in body wall musculature; intestine; neurons; pharynx; and spermatheca. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human CAP1 (cyclase associated actin cytoskeleton regulatory protein 1) and CAP2 (cyclase associated actin cytoskeleton regulatory protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See cas-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 8

Sequence:: Chromosome: X; NC_003284.9 (16807455..16813656, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CAS-1, a cyclase-associated protein in Caenorhabditis elegans, promotes ADF/cofilin-dependent actin filament turnover.
Title: CAS-1, a C. elegans cyclase-associated protein, is required for sarcomeric actin assembly in striated muscle.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F41G4.2 (e-PCR)
- UniSTS:317588

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables adenylate cyclase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cAMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoskeleton organization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Adenylyl cyclase-associated protein;C-CAP/cofactor C-like domain-containing protein

NP_001360035.1

Confirmed by transcript evidence

NP_510713.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

16807455..16813656 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001373613.3 → NP_001360035.1 C-CAP/cofactor C-like domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q95YA9

Conserved Domains (3) summary

PRK10263
Location:481 → 570

PRK10263; DNA translocase FtsK; Provisional

pfam01213
Location:748 → 1017

CAP_N; Adenylate cyclase associated (CAP) N terminal

pfam08603
Location:1037 → 1194

CAP_C; Adenylate cyclase associated (CAP) C terminal
NM_078312.7 → NP_510713.1 Adenylyl cyclase-associated protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_510713.1

Status: REVIEWED

UniProtKB/TrEMBL

H2L023

Conserved Domains (3) summary

smart00673
Location:414 → 451

CARP; Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product

pfam01213
Location:8 → 317

CAP_N; Adenylate cyclase associated (CAP) N terminal

pfam08603
Location:346 → 494

CAP_C; Adenylate cyclase associated (CAP) C terminal