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    tap-1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [ Caenorhabditis elegans ]

    Gene ID: 181556, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tap-1
    Official Full Name
    TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
    Primary source
    WormBase:WBGene00006524
    Locus tag
    CELE_C44H4.5
    See related
    AllianceGenome:WB:WBGene00006524
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables mitogen-activated protein kinase kinase kinase binding activity and protein kinase activator activity. Involved in endodermal cell fate specification and negative regulation of Ras protein signal transduction. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including anal depressor muscle; coelomocyte; excretory cell; nervous system; and pharynx. Orthologous to human TAB1 (TGF-beta activated kinase 1 (MAP3K7) binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tap-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    9
    Sequence:
    Chromosome: X; NC_003284.9 (14589624..14591821)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Chorein N-terminal domain-containing protein Neighboring gene Leucine-rich repeat-containing protein let-4 Neighboring gene Leucine-rich repeat-containing protein let-4 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Transmembrane protein Neighboring gene Protein kinase domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An evolutionarily conserved motif in the TAB1 C-terminal region is necessary for interaction with and activation of TAK1 MAPKKK. Ono K, et al. J Biol Chem, 2001 Jun 29. PMID 11323434
    2. The CRAL/TRIO and GOLD domain protein TAP-1 regulates RAF-1 activation. Johnson KG, et al. Dev Biol, 2010 May 15. PMID 20230813, Free PMC Article
    3. β-Catenin-related protein WRM-1 is a multifunctional regulatory subunit of the LIT-1 MAPK complex. Yang XD, et al. Proc Natl Acad Sci U S A, 2015 Jan 13. PMID 25548171, Free PMC Article
    4. MAP kinase and Wnt pathways converge to downregulate an HMG-domain repressor in Caenorhabditis elegans. Meneghini MD, et al. Nature, 1999 Jun 24. PMID 10391246
    5. The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF. Ishitani T, et al. Nature, 1999 Jun 24. PMID 10391247

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables mitogen-activated protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mitogen-activated protein kinase kinase kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endodermal cell fate specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of Ras protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression, epigenetic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
    NP_510428.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      14589624..14591821
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078027.7 → NP_510428.1  TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510428.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EEM6
      Conserved Domains (1) summary
      cd00143
      Location:21 → 327
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EEM6.1

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