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    M03D4.4 C2H2-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177375, updated on 9-Dec-2024

    Summary

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    Official Symbol
    M03D4.4
    Official Full Name
    C2H2-type domain-containing protein
    Primary source
    WormBase:WBGene00019751
    Locus tag
    CELE_M03D4.4
    See related
    AllianceGenome:WB:WBGene00019751
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in pharyngeal muscle cell. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human VEZF1 (vascular endothelial zinc finger 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See M03D4.4 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    8
    Sequence:
    Chromosome: IV; NC_003282.8 (6121773..6127302, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Kinesin-like protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    C2H2-type domain-containing protein
    NP_001023313.1
    • Confirmed by transcript evidence
    NP_001023314.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      6121773..6127302 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001028142.7 → NP_001023313.1  C2H2-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023313.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21494
      Conserved Domains (3) summary
      sd00017
      Location:118 → 138
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:172 → 194
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:102 → 127
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001028143.6 → NP_001023314.1  C2H2-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023314.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5TYL4
      Conserved Domains (2) summary
      sd00017
      Location:69 → 89
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:53 → 78
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version

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