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    dma-1 LRRCT domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 187968, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dma-1
    Official Full Name
    LRRCT domain-containing protein
    Primary source
    WormBase:WBGene00011345
    Locus tag
    CELE_T01G9.3
    See related
    AllianceGenome:WB:WBGene00011345
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables protease binding activity. Involved in neuron development and regulation of cell morphogenesis. Located in dendrite membrane. Is expressed in head neurons; sensory neurons; somatic nervous system; and vulva. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dma-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (8281969..8284477)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene NAM-associated domain-containing protein Neighboring gene ncRNA Neighboring gene ZP domain-containing protein Neighboring gene PHAF1 protein T01G9.2 Neighboring gene Casein kinase II subunit beta Neighboring gene Nuclear pore complex protein Nup85

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The transmembrane LRR protein DMA-1 promotes dendrite branching and growth in C. elegans. Liu OW, et al. Nat Neurosci, 2011 Dec 4. PMID 22138642, Free PMC Article
    2. Specific N-glycans regulate an extracellular adhesion complex during somatosensory dendrite patterning. Rahman M, et al. EMBO Rep, 2022 Jul 5. PMID 35586945, Free PMC Article
    3. Muscle- and Skin-Derived Cues Jointly Orchestrate Patterning of Somatosensory Dendrites. Díaz-Balzac CA, et al. Curr Biol, 2016 Sep 12. PMID 27451901, Free PMC Article
    4. A two-step actin polymerization mechanism drives dendrite branching. Shi R, et al. Neural Dev, 2021 Jul 19. PMID 34281597, Free PMC Article
    5. The unfolded protein response is required for dendrite morphogenesis. Wei X, et al. Elife, 2015 Jun 8. PMID 26052671, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mutually exclusive dendritic arbors in C. elegans neurons share a common architecture and convergent molecular cues.
      Title: Mutually exclusive dendritic arbors in C. elegans neurons share a common architecture and convergent molecular cues.
    2. The experiments suggest that HPO-30/Claudin localizes the DMA-1/LRR-TM receptor on polymodal somatosensory neuron dendrites, which in turn can control dendrite patterning by directly modulating F-actin dynamics through TIAM-1/GEF.
      Title: TIAM-1/GEF can shape somatosensory dendrites independently of its GEF activity by regulating F-actin localization.
    3. The authors show that KPC-1, a Caenorhabditis elegans furin homolog, regulates the level of the branching receptor DMA-1 on dendrites by targeting it to late endosomes.
      Title: Precise regulation of the guidance receptor DMA-1 by KPC-1/Furin instructs dendritic branching decisions.
    4. dendritic branch distribution depends on the balance between the molecular motors UNC-116 and dynein, and we propose that RAB-10 regulates dendrite morphology by balancing the activity of these motors to the transmembrane receptor DMA-1.
      Title: RAB-10 Regulates Dendritic Branching by Balancing Dendritic Transport.
    5. The ligand complex SAX-7/L1CAM and MNR-1 function at defined locations in the surrounding hypodermal tissue, whereas DMA-1 acts as the cognate receptor on the sensory neuron PVD. Mutations in this complex lead to dramatic defects in the formation, stabilization, and organization of the dendritic arbor.
      Title: An extracellular adhesion molecule complex patterns dendritic branching and morphogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protease binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dendrite guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dendrite self-avoidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in dendrite self-avoidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of dendrite morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of dendrite extension IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of dendrite extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of dendrite morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in dendrite membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    LRRCT domain-containing protein
    NP_492253.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8281969..8284477
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059852.6 → NP_492253.1  LRRCT domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492253.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22075
      Conserved Domains (4) summary
      COG4886
      Location:136 → 430
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:113 → 136
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:90 → 147
      LRR_8; Leucine rich repeat
      cl15307
      Location:438 → 478
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    Nucleotide Protein
    Heading Accession and Version

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