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    nac-3 Sodium-dependent high-affinity dicarboxylate transporter 3 [ Caenorhabditis elegans ]

    Gene ID: 176429, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nac-3
    Official Full Name
    Sodium-dependent high-affinity dicarboxylate transporter 3
    Primary source
    WormBase:WBGene00003519
    Locus tag
    CELE_K08E5.2
    See related
    AllianceGenome:WB:WBGene00003519
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables high-affinity sodium:dicarboxylate symporter activity and succinate transmembrane transporter activity. Involved in determination of adult lifespan and succinate transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in alimentary system. Orthologous to several human genes including SLC13A2 (solute carrier family 13 member 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nac-3 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    8
    Sequence:
    Chromosome: III; NC_003281.10 (10152795..10157925)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Transmembrane cell adhesion receptor mua-3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Membrane topology structure of human high-affinity, sodium-dependent dicarboxylate transporter. Bai XY, et al. FASEB J, 2007 Aug. PMID 17426067
    2. Structural and functional characteristics of two sodium-coupled dicarboxylate transporters (ceNaDC1 and ceNaDC2) from Caenorhabditis elegans and their relevance to life span. Fei YJ, et al. J Biol Chem, 2003 Feb 21. PMID 12480943
    3. Relevance of NAC-2, an Na+-coupled citrate transporter, to life span, body size and fat content in Caenorhabditis elegans. Fei YJ, et al. Biochem J, 2004 Apr 1. PMID 14678010, Free PMC Article
    4. No influence of Indy on lifespan in Drosophila after correction for genetic and cytoplasmic background effects. Toivonen JM, et al. PLoS Genet, 2007 Jun. PMID 17571923, Free PMC Article
    5. Dietary restriction in C. elegans: from rate-of-living effects to nutrient sensing pathways. Walker G, et al. Mech Ageing Dev, 2005 Sep. PMID 15896824

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Topography of 11 transmembrane domains with an extracellular C terminus and an intracellular N terminus of this protein.
      Title: Membrane topology structure of human high-affinity, sodium-dependent dicarboxylate transporter.
    2. structural and functional characteristics of two sodium-coupled dicarboxylate transporters and their relevance to life span.
      Title: Structural and functional characteristics of two sodium-coupled dicarboxylate transporters (ceNaDC1 and ceNaDC2) from Caenorhabditis elegans and their relevance to life span.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables citrate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables high-affinity sodium:dicarboxylate symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables succinate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables succinate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in citrate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in succinate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in succinate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in succinate transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Sodium-dependent high-affinity dicarboxylate transporter 3
    NP_001022673.1
    • Confirmed by transcript evidence
    NP_001379390.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      10152795..10157925
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027502.5 → NP_001022673.1  Sodium-dependent high-affinity dicarboxylate transporter 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022673.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21339, Q86G93, Q86R85
      Conserved Domains (2) summary
      cd01115
      Location:83 → 543
      SLC13_permease; Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is ...
      TIGR00785
      Location:84 → 539
      dass; anion transporter

    2. NM_001392186.1 → NP_001379390.1  Sodium-dependent high-affinity dicarboxylate transporter 3 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cd01115
      Location:2 → 455
      SLC13_permease; Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q21339.3

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