dnc-1 Dynactin subunit 1;Dynein associated protein domain-containing protein [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: dnc-1
Official Full Name: Dynactin subunit 1;Dynein associated protein domain-containing protein
Primary source: WormBase:WBGene00001017
Locus tag: CELE_ZK593.5
See related: AllianceGenome:WB:WBGene00001017
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable dynein intermediate chain binding activity and microtubule binding activity. Involved in several processes, including centrosomal and pronuclear rotation; establishment of mitotic spindle orientation; and pronuclear migration. Located in several cellular components, including kinetochore; microtubule cytoskeleton; and midbody. Part of dynactin complex. Is expressed in AB; P0; and Psub1. Human ortholog(s) of this gene implicated in Perry syndrome; amyotrophic lateral sclerosis type 1; and autosomal dominant distal hereditary motor neuronopathy 14. Orthologous to human DCTN1 (dynactin subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See dnc-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 14

Sequence:: Chromosome: IV; NC_003282.8 (10926720..10933203, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we dissect the role of dynactin's microtubule binding activity, located in the p150 CAP-Gly domain and an adjacent basic patch, in the C. elegans zygote. Our results suggest that p150 GAP-Gly domain binding to microtubules promotes initiation of dynein-mediated organelle transport in the dividing one-cell embryo, and that this function of p150 is critical for generating cytoplasmic pulling forces for centrosome
Title: Dynactin binding to tyrosinated microtubules promotes centrosome centration in C. elegans by enhancing dynein-mediated organelle transport.
results suggest that decreased expression of dynactin 1 induces motor neuron degeneration and that the transport of autophagosomes is a novel and substantial therapeutic target for motor neuron degeneration
Title: dnc-1/dynactin 1 knockdown disrupts transport of autophagosomes and induces motor neuron degeneration.
putative UNC-104 interactors, namely UNC-16(JIP3), DNC-1(DCTN1/Glued) and SYD-2(Liprin-alpha), inherit different functions in steering UNC-104 to specific sub-cellular locations in the neuron
Title: Sub-cellular distribution of UNC-104(KIF1A) upon binding to adaptors as UNC-16(JIP3), DNC-1(DCTN1/Glued) and SYD-2(Liprin-α) in C. elegans neurons.
Src and Wnt signaling regulate dynactin accumulation to the P2-EMS cell border in C. elegans embryos
Title: Src and Wnt signaling regulate dynactin accumulation to the P2-EMS cell border in C. elegans embryos.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

ZK593.7 (e-PCR)
- UniSTS:321110

ZK593.5 (e-PCR)
- UniSTS:310516

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cytoskeletal protein binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables dynein intermediate chain binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables microtubule binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in centrosomal and pronuclear rotation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of mitotic spindle orientation	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of mitotic spindle orientation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pronuclear migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in astral microtubule	IDA Inferred from Direct Assay more info	PubMed
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
part_of dynactin complex	IDA Inferred from Direct Assay more info	PubMed
part_of dynein complex	IEA Inferred from Electronic Annotation more info
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
part_of microtubule associated complex	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule plus-end	IDA Inferred from Direct Assay more info	PubMed
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
located_in spindle	IDA Inferred from Direct Assay more info	PubMed
located_in spindle midzone	IDA Inferred from Direct Assay more info	PubMed
is_active_in spindle pole	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: Dynactin subunit 1;Dynein associated protein domain-containing protein

NP_001255521.1

Confirmed by transcript evidence

NP_001255522.1

Confirmed by transcript evidence

NP_001263781.1

Confirmed by transcript evidence

NP_001263782.1

Confirmed by transcript evidence

NP_001379109.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

10926720..10933203 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392398.1 → NP_001379109.1 Dynactin subunit 1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q23542

Conserved Domains (6) summary

PHA02682
Location:166 → 278

PHA02682; ORF080 virion core protein; Provisional

COG1196
Location:341 → 623

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

PRK12323
Location:74 → 348

PRK12323; DNA polymerase III subunit gamma/tau

pfam01302
Location:5 → 68

CAP_GLY; CAP-Gly domain

pfam10174
Location:1025 → 1263

Cast; RIM-binding protein of the cytomatrix active zone

pfam12455
Location:605 → 889

Dynactin; Dynein associated protein
NM_001268592.3 → NP_001255521.1 Dynactin subunit 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255521.1

Status: REVIEWED

UniProtKB/TrEMBL

E2JKZ0

Conserved Domains (4) summary

PHA03247
Location:71 → 306

PHA03247; large tegument protein UL36; Provisional

COG1196
Location:366 → 648

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam01302
Location:5 → 68

CAP_GLY; CAP-Gly domain

pfam12455
Location:630 → 914

Dynactin; Dynein associated protein
NM_001276852.4 → NP_001263781.1 Dynactin subunit 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001263781.1

Status: REVIEWED

UniProtKB/TrEMBL

L8E938

Conserved Domains (4) summary

PHA03247
Location:71 → 250

PHA03247; large tegument protein UL36; Provisional

COG1196
Location:313 → 595

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam01302
Location:5 → 68

CAP_GLY; CAP-Gly domain

pfam12455
Location:577 → 861

Dynactin; Dynein associated protein
NM_001276853.3 → NP_001263782.1 Dynactin subunit 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001263782.1

Status: REVIEWED

UniProtKB/TrEMBL

L8EC32

Conserved Domains (4) summary

PHA03247
Location:87 → 278

PHA03247; large tegument protein UL36; Provisional

COG1196
Location:338 → 620

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam01302
Location:5 → 68

CAP_GLY; CAP-Gly domain

pfam12455
Location:602 → 886

Dynactin; Dynein associated protein
NM_001268593.3 → NP_001255522.1 Dynein associated protein domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255522.1

Status: REVIEWED

UniProtKB/TrEMBL

E2JKY8

Conserved Domains (2) summary

COG1196
Location:103 → 385

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam12455
Location:367 → 651

Dynactin; Dynein associated protein