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    nhx-6 Sodium/hydrogen exchanger [ Caenorhabditis elegans ]

    Gene ID: 186511, updated on 9-Dec-2024

    Summary

    Official Symbol
    nhx-6
    Official Full Name
    Sodium/hydrogen exchanger
    Primary source
    WormBase:WBGene00003734
    Locus tag
    CELE_F58E1.6
    See related
    AllianceGenome:WB:WBGene00003734
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Predicted to be involved in potassium ion transmembrane transport; regulation of intracellular pH; and sodium ion import across plasma membrane. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in intestine. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 19; congenital secretory sodium diarrhea 8; congestive heart failure; and end stage renal disease. Orthologous to several human genes including SLC9A2 (solute carrier family 9 member A2); SLC9A3 (solute carrier family 9 member A3); and SLC9A5 (solute carrier family 9 member A5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See nhx-6 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    9
    Sequence:
    Chromosome: II; NC_003280.10 (1670829..1674401)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Homeobox domain-containing protein Neighboring gene SXP/RAL-2 family protein Ani s 5-like cation-binding domain-containing protein Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene F-box associated domain-containing protein Neighboring gene pseudo

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables potassium:proton antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sodium:proton antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sodium:proton antiporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in monoatomic cation transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of intracellular pH IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of pH IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sodium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    Sodium/hydrogen exchanger
    NP_001022214.1
    • Partially confirmed by transcript evidence
    NP_001022215.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      1670829..1674401
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027044.4NP_001022215.1  Sodium/hydrogen exchanger [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022215.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L039, Q8T5R6
      Conserved Domains (2) summary
      TIGR00840
      Location:43551
      b_cpa1; sodium/hydrogen exchanger 3
      pfam00999
      Location:104456
      Na_H_Exchanger; Sodium/hydrogen exchanger family
    2. NM_001027043.3NP_001022214.1  Sodium/hydrogen exchanger [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022214.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T5R6, Q9TZH0
      Conserved Domains (1) summary
      pfam00999
      Location:104456
      Na_H_Exchanger; Sodium/hydrogen exchanger family