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    cyp-44A1 putative cytochrome P450 CYP44 [ Caenorhabditis elegans ]

    Gene ID: 173936, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cyp-44A1
    Official Full Name
    putative cytochrome P450 CYP44
    Primary source
    WormBase:WBGene00000375
    Locus tag
    CELE_ZK177.5
    See related
    AllianceGenome:WB:WBGene00000375
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); bone disease (multiple); cerebrotendinous xanthomatosis; gastrointestinal system cancer (multiple); and lung cancer (multiple). Orthologous to several human genes including CYP24A1 (cytochrome P450 family 24 subfamily A member 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cyp-44A1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    9
    Sequence:
    Chromosome: II; NC_003280.10 (5504044..5505975)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Glycine-rich cell wall structural protein Neighboring gene Uncharacterized protein Neighboring gene WD repeat-containing protein fzy-1 Neighboring gene Protein npp-24 Neighboring gene Deoxynucleoside triphosphate triphosphohydrolase sahd-1 Neighboring gene C2H2-type domain-containing protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of nonviable genes affecting touch sensitivity in Caenorhabditis elegans using neuronally enhanced feeding RNA interference. Chen X, et al. G3 (Bethesda), 2015 Jan 9. PMID 25575561, Free PMC Article
    2. Oocyte signals derived from polyunsaturated fatty acids control sperm recruitment in vivo. Kubagawa HM, et al. Nat Cell Biol, 2006 Oct. PMID 16998478
    3. CEST-2.2 overexpression alters lipid metabolism and extends longevity of mitochondrial mutants. Piazzesi A, et al. EMBO Rep, 2022 May 4. PMID 35297148, Free PMC Article
    4. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
    5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative cytochrome P450 CYP44
    NP_495052.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      5504044..5505975
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062651.7 → NP_495052.1  putative cytochrome P450 CYP44 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495052.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09660
      Conserved Domains (1) summary
      cl12078
      Location:34 → 477
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09660.2

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