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    hecw-1 E3 ubiquitin-protein ligase hecw-1 [ Caenorhabditis elegans ]

    Gene ID: 175438, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hecw-1
    Official Full Name
    E3 ubiquitin-protein ligase hecw-1
    Primary source
    WormBase:WBGene00009738
    Locus tag
    CELE_F45H7.6
    See related
    AllianceGenome:WB:WBGene00009738
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ubiquitin protein ligase activity. Involved in regulation of defense response to bacterium. Predicted to be active in cytoplasm. Is expressed in SMDVL and head neurons. Orthologous to human HECW1 (HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1) and HECW2 (HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hecw-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    22
    Sequence:
    Chromosome: III; NC_003281.10 (3377396..3389970, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Lys Neighboring gene ncRNA Neighboring gene ELMO domain-containing protein;ELMO domain-containing protein C56G7.3 Neighboring gene Myosin regulatory light chain Neighboring gene Conserved regulator of innate immunity protein 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Natural polymorphisms in C. elegans HECW-1 E3 ligase affect pathogen avoidance behaviour. Chang HC, et al. Nature, 2011 Nov 16. PMID 22089131, Free PMC Article
    2. Deficiency of Innate Immunity against Pseudomonas aeruginosa Enhances Behavioral Avoidance via the HECW-1/NPR-1 Module in Caenorhabditis elegans. Bai H, et al. Infect Immun, 2021 Sep 16. PMID 34310887, Free PMC Article
    3. Ubiquitin-mediated pathways in C. elegans. Kipreos ET. WormBook, 2005 Dec 1. PMID 18050424, Free PMC Article
    4. The F-box protein family. Kipreos ET, et al. Genome Biol, 2000. PMID 11178263, Free PMC Article
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of dendrite morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase hecw-1
    NP_001317872.1
    • Partially confirmed by transcript evidence
    NP_497697.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      3377396..3389970 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065296.5 → NP_497697.2  E3 ubiquitin-protein ligase hecw-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497697.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EEJ0
      Conserved Domains (3) summary
      smart00456
      Location:230 → 261
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:545 → 871
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:520 → 872
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    2. NM_001330981.3 → NP_001317872.1  E3 ubiquitin-protein ligase hecw-1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1C3NSJ1, G5EEJ0, Q09291
      Conserved Domains (3) summary
      smart00456
      Location:603 → 634
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:918 → 1244
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam07735
      Location:230 → 285
      FBA_2; F-box associated
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09291.2

    Gene LinkOut

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