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    egas-2 EGF-like domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 190561, updated on 9-Dec-2024

    Summary

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    Official Symbol
    egas-2
    Official Full Name
    EGF-like domain-containing protein
    Primary source
    WormBase:WBGene00013487
    Locus tag
    CELE_Y69H2.12
    See related
    AllianceGenome:WB:WBGene00013487
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ligand-gated sodium channel activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See egas-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    18
    Sequence:
    Chromosome: V; NC_003283.11 (18650343..18656165)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene EGF-like domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Follistatin-like domain-containing protein;TIL domain-containing protein Neighboring gene TIL domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Physiological insight into the conserved properties of Caenorhabditis elegans acid-sensing degenerin/epithelial sodium channels. Kaulich E, et al. J Physiol, 2023 May. PMID 36200489, Free PMC Article
    2. Locomotion modulates olfactory learning through proprioception in C. elegans. Zhan X, et al. Nat Commun, 2023 Jul 27. PMID 37500635, Free PMC Article
    3. Mechanosensation. Goodman MB. WormBook, 2006 Jan 6. PMID 18050466, Free PMC Article
    4. A database of Caenorhabditis elegans behavioral phenotypes. Yemini E, et al. Nat Methods, 2013 Sep. PMID 23852451, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligand-gated sodium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    EGF-like domain-containing protein
    NP_507640.2
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      18650343..18656165
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_075239.2 → NP_507640.2  EGF-like domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_507640.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U1T8
      Conserved Domains (1) summary
      pfam00858
      Location:650 → 908
      ASC; Amiloride-sensitive sodium channel
    Nucleotide Protein
    Heading Accession and Version

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