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    cyp-14A5 CYtochrome P450 family [ Caenorhabditis elegans ]

    Gene ID: 178926, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cyp-14A5
    Official Full Name
    CYtochrome P450 family
    Primary source
    WormBase:WBGene00000373
    Locus tag
    CELE_F08F3.7
    See related
    AllianceGenome:WB:WBGene00000373
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Involved in response to gamma radiation. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hepatitis; extrapyramidal and movement disease; head and neck squamous cell carcinoma; hereditary spastic paraplegia 56; and leukemia (multiple). Orthologous to several human genes including CYP2D6 (cytochrome P450 family 2 subfamily D member 6); CYP2D7 (cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)); and CYP2U1 (cytochrome P450 family 2 subfamily U member 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cyp-14A5 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (5421018..5423282, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene F-box domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ammonium transporter AmtB-like domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Minimal modulation of macrocyclic lactone susceptibility in Caenorhabditis elegans following inhibition of cytochrome P450 monooxygenase activity. Yilmaz E, et al. Exp Parasitol, 2019 May. PMID 30946841
    2. Cytochrome P450-dependent metabolism of PCB52 in the nematode Caenorhabditis elegans. Schäfer P, et al. Arch Biochem Biophys, 2009 Aug 1. PMID 19563772
    3. CYP14 family in Caenorhabditis elegans: Mitochondrial function, detoxification, and lifespan. Lim SYM, et al. J Appl Toxicol, 2024 Nov. PMID 38472099
    4. The DNA damage-inducible C. elegans tankyrase is a nuclear protein closely linked to chromosomes. White C, et al. Mol Cell Biochem, 2009 Apr. PMID 19104912
    5. Proton Microbeam Targeted Irradiation of the Gonad Primordium Region Induces Developmental Alterations Associated with Heat Shock Responses and Cuticle Defense in Caenorhabditis elegans. Beaudier P, et al. Biology (Basel), 2023 Oct 27. PMID 37997971, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to gamma radiation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CYtochrome P450 family
    NP_504435.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      5421018..5423282 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072034.6 → NP_504435.1  CYtochrome P450 family [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504435.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q27531
      Conserved Domains (1) summary
      pfam00067
      Location:27 → 484
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version

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