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    cest-3 Carboxylic ester hydrolase [ Caenorhabditis elegans ]

    Gene ID: 181385, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cest-3
    Official Full Name
    Carboxylic ester hydrolase
    Primary source
    WormBase:WBGene00008451
    Locus tag
    CELE_E01G6.3
    See related
    AllianceGenome:WB:WBGene00008451
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable carboxylic ester hydrolase activity. Involved in ascaroside biosynthetic process. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cest-3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    12
    Sequence:
    Chromosome: X; NC_003284.9 (12241646..12244657)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Carboxylesterase type B domain-containing protein Neighboring gene Carboxylic ester hydrolase Neighboring gene AAA_23 domain-containing protein;RecF/RecN/SMC N-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Natural genetic variation in the pheromone production of C. elegans. Lee D, et al. Proc Natl Acad Sci U S A, 2023 Jun 27. PMID 37339205, Free PMC Article
    2. A Large Family of Enzymes Responsible for the Modular Architecture of Nematode Pheromones. Faghih N, et al. J Am Chem Soc, 2020 Aug 12. PMID 32702987, Free PMC Article
    3. Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain. Dube F, et al. PLoS One, 2023. PMID 37141255, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ascaroside biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Carboxylic ester hydrolase
    NP_510042.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      12241646..12244657
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077641.7 → NP_510042.2  Carboxylic ester hydrolase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510042.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EC03
      Conserved Domains (2) summary
      COG0657
      Location:118 → 254
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      cl21494
      Location:23 → 496
      Abhydrolase; alpha/beta hydrolases
    Nucleotide Protein
    Heading Accession and Version

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