trpa-1 Ion transport domain-containing protein;Transient receptor potential cation channel subfamily A member 1 homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: trpa-1
Official Full Name: Ion transport domain-containing protein;Transient receptor potential cation channel subfamily A member 1 homolog
Primary source: WormBase:WBGene00007801
Locus tag: CELE_C29E6.2
See related: AllianceGenome:WB:WBGene00007801
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable monoatomic ion channel activity. Predicted to be involved in monoatomic ion transmembrane transport. Located in neuronal cell body and non-motile cilium. Is expressed in several structures, including pharynx; rectal gland cell; sensory neurons; ventral nerve cord; and vulva. Human ortholog(s) of this gene implicated in familial episodic pain syndrome 1. Orthologous to human TRPA1 (transient receptor potential cation channel subfamily A member 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See trpa-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 11

Sequence:: Chromosome: IV; NC_003282.8 (11864526..11875733)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study reveals that TRPA-1, a cold-sensitive TRP channel, detects temperature drop in the environment to extend lifespan. This effect requires cold-induced, TRPA-1-mediated calcium influx and a calcium-sensitive PKC that signals to the transcription factor DAF-16/FOXO.
Title: A genetic program promotes C. elegans longevity at cold temperatures via a thermosensitive TRP channel.
harsh touch specifically required the DEG/ENaC proteins MEC-10 and DEGT-1 (F25D1.4), which represent putative components of a harsh touch mechanotransduction complex; responses to cold required the TRPA-1 channel and were MEC-10 and DEGT-1 independent
Title: Specific roles for DEG/ENaC and TRP channels in touch and thermosensation in C. elegans nociceptors.
This study demonstrates that trpa-1 encodes an ion channel that can be activated in response to mechanical pressure and is required for mechanosensory neuron function.
Title: Caenorhabditis elegans TRPA-1 functions in mechanosensation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C29E6.2 (e-PCR)
- UniSTS:321246

C29E6.6 (e-PCR)
- UniSTS:321247

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in response to stimulus	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in non-motile cilium	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Ion transport domain-containing protein;Transient receptor potential cation channel subfamily A member 1 homolog

NP_001294083.1

Confirmed by transcript evidence

NP_502249.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

11864526..11875733

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001307154.4 → NP_001294083.1 Ion transport domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294083.1

Status: REVIEWED

UniProtKB/TrEMBL

A5HJZ7, N1NV19

Conserved Domains (4) summary

PHA03095
Location:68 → 404

PHA03095; ankyrin-like protein; Provisional

TIGR00870
Location:440 → 1066

trp; transient-receptor-potential calcium channel protein

sd00045
Location:472 → 503

ANK; ANK repeat [structural motif]

pfam00520
Location:813 → 1079

Ion_trans; Ion transport protein
NM_069848.8 → NP_502249.3 Transient receptor potential cation channel subfamily A member 1 homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_502249.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q18297

UniProtKB/TrEMBL

A5HJZ7

Conserved Domains (5) summary

cd00204
Location:78 → 227

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam00520
Location:857 → 1080

Ion_trans; Ion transport protein

pfam12796
Location:316 → 409

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:51 → 104

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:473 → 504

ANK; ANK repeat [structural motif]