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    pamn-1 putative peptidylglycine alpha-hydroxylating monooxygenase [ Caenorhabditis elegans ]

    Gene ID: 266833, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pamn-1
    Official Full Name
    putative peptidylglycine alpha-hydroxylating monooxygenase
    Primary source
    WormBase:WBGene00020556
    Locus tag
    CELE_T19B4.1
    See related
    AllianceGenome:WB:WBGene00020556
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable copper ion binding activity; peptidylamidoglycolate lyase activity; and peptidylglycine monooxygenase activity. Predicted to be involved in peptide metabolic process. Predicted to be located in membrane. Predicted to be active in extracellular region. Is expressed in intestine and nervous system. Orthologous to human PAM (peptidylglycine alpha-amidating monooxygenase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pamn-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    12
    Sequence:
    Chromosome: I; NC_003279.8 (5702156..5705553)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Adenine phosphoribosyltransferase;adenine phosphoribosyltransferase Neighboring gene Netrin receptor unc-40 Neighboring gene RanBP2-type domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene LIM/homeobox protein lim-7 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Axon-Dependent Patterning and Maintenance of Somatosensory Dendritic Arbors. Ramirez-Suarez NJ, et al. Dev Cell, 2019 Jan 28. PMID 30661986, Free PMC Article
    2. The relationship between intraflagellar transport and upstream protein trafficking pathways and macrocyclic lactone resistance in Caenorhabditis elegans. Brinzer RA, et al. G3 (Bethesda), 2024 Mar 6. PMID 38227795, Free PMC Article
    3. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
    4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidylamidoglycolate lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidylglycine monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative peptidylglycine alpha-hydroxylating monooxygenase
    NP_001367424.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      5702156..5705553
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001380351.3 → NP_001367424.1  putative peptidylglycine alpha-hydroxylating monooxygenase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P83388, P91458
      Conserved Domains (3) summary
      cd14958
      Location:355 → 656
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:61 → 146
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:168 → 289
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P83388.2

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