pgp-8 P-GlycoProtein related [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pgp-8
Official Full Name: P-GlycoProtein related
Primary source: WormBase:WBGene00004002
Locus tag: CELE_T21E8.3
See related: AllianceGenome:WB:WBGene00004002
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in head neurons. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); cholestasis (multiple); drug dependence (multiple); and human immunodeficiency virus infectious disease (multiple). Orthologous to several human genes including ABCB1 (ATP binding cassette subfamily B member 1); ABCB11 (ATP binding cassette subfamily B member 11); and ABCB4 (ATP binding cassette subfamily B member 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See pgp-8 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 16

Sequence:: Chromosome: X; NC_003284.9 (10859301..10864422, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T21E8.3 (e-PCR)
- UniSTS:308076

T21E8.2 (e-PCR)
- UniSTS:310933

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in response to chemical	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: P-GlycoProtein related

NP_509811.2

Product from WormBase gene class pgp;
Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

10859301..10864422 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_077410.6 → NP_509811.2 P-GlycoProtein related [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509811.2

Status: REVIEWED

UniProtKB/TrEMBL

G5EG03

Conserved Domains (4) summary

cd03249
Location:382 → 617

ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins

PTZ00265
Location:29 → 1241

PTZ00265; multidrug resistance protein (mdr1); Provisional

pfam00664
Location:685 → 953

ABC_membrane; ABC transporter transmembrane region

cl00549
Location:44 → 326

ABC_membrane; ABC transporter transmembrane region