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    rsu-1 Ras suppressor protein 1 [ Caenorhabditis elegans ]

    Gene ID: 175451, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rsu-1
    Official Full Name
    Ras suppressor protein 1
    Primary source
    WormBase:WBGene00007924
    Locus tag
    CELE_C34C12.5
    See related
    AllianceGenome:WB:WBGene00007924
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in innate immune response. Is expressed in body wall musculature; distal tip cell; epithelial cell; non-striated muscle; and ventral cord neurons. Orthologous to human RSU1 (Ras suppressor protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rsu-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (3472003..3473722)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Serine/threonine-protein phosphatase 6 catalytic subunit Neighboring gene SMall Integral Membrane protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene CRAL-TRIO domain-containing protein C34C12.6 Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Preventing Illegitimate Extrasynaptic Acetylcholine Receptor Clustering Requires the RSU-1 Protein. Pierron M, et al. J Neurosci, 2016 Jun 15. PMID 27307240, Free PMC Article
    2. RSU-1 regulates the integrity of dense bodies in muscle cells of aging Caenorhabditis elegans. Jiang L, et al. iScience, 2024 Jun 21. PMID 38784006, Free PMC Article
    3. RSU-1 Maintains Integrity of Caenorhabditis elegans Vulval Muscles by Regulating α-Actinin. Wang X, et al. G3 (Bethesda), 2020 Jul 7. PMID 32461202, Free PMC Article
    4. Distinct patterns of gene and protein expression elicited by organophosphorus pesticides in Caenorhabditis elegans. Lewis JA, et al. BMC Genomics, 2009 Apr 29. PMID 19402892, Free PMC Article
    5. Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms. Skop AR, et al. Science, 2004 Jul 2. PMID 15166316, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in innate immune response HEP PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ras suppressor protein 1
    NP_497716.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      3472003..3473722
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065315.7 → NP_497716.1  Ras suppressor protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497716.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q09497
      Conserved Domains (4) summary
      cd00116
      Location:53 → 164
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:36 → 57
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:57 → 95
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:57 → 114
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version

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