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    hog-1 HintN domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180851, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hog-1
    Official Full Name
    HintN domain-containing protein
    Primary source
    WormBase:WBGene00001984
    Locus tag
    CELE_W06B11.4
    See related
    AllianceGenome:WB:WBGene00001984
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in protein autoprocessing. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Is expressed in rectal epithelium. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hog-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    7
    Sequence:
    Chromosome: X; NC_003284.9 (5851953..5854263, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene PUM-HD domain-containing protein Neighboring gene ncRNA Neighboring gene Alpha-tubulin N-acetyltransferase 2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hrk1 plays both Hog1-dependent and -independent roles in controlling stress response and antifungal drug resistance in Cryptococcus neoformans. Kim SY, et al. PLoS One, 2011 Apr 13. PMID 21533251, Free PMC Article
    2. Warthog and groundhog, novel families related to hedgehog. Bürglin TR. Curr Biol, 1996 Sep 1. PMID 8805384
    3. Transcriptomic Analysis Reveals JAK2/MPL-Independent Effects of Calreticulin Mutations in a C. elegans Model. Guijarro-Hernández A, et al. Cells, 2023 Jan 2. PMID 36611979, Free PMC Article
    4. Homologs of the Hh signalling network in C. elegans. Bürglin TR, et al. WormBook, 2006 Jan 28. PMID 18050469, Free PMC Article
    5. Caenorhabditis elegans has scores of hedgehog-related genes: sequence and expression analysis. Aspöck G, et al. Genome Res, 1999 Oct. PMID 10523520

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. findings suggest that Hrk1 plays both Hog1-dependent and -independent roles in stress and antifungal drug susceptibility and virulence factor production in C. neoformans
      Title: Hrk1 plays both Hog1-dependent and -independent roles in controlling stress response and antifungal drug resistance in Cryptococcus neoformans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in protein autoprocessing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    HintN domain-containing protein
    NP_001257028.1
    • Confirmed by transcript evidence
    NP_001257029.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      5851953..5854263 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001270100.3 → NP_001257029.1  HintN domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001257029.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23193
      Conserved Domains (1) summary
      cd00081
      Location:1 → 141
      Hint; Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein, ...

    2. NM_001270099.3 → NP_001257028.1  HintN domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001257028.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KZR5
      Conserved Domains (1) summary
      cd00081
      Location:44 → 191
      Hint; Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein, ...
    Nucleotide Protein
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