mab-10 NAB transcription cofactor mab-10 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mab-10
Official Full Name: NAB transcription cofactor mab-10
Primary source: WormBase:WBGene00003107
Locus tag: CELE_R166.1
See related: AllianceGenome:WB:WBGene00003107
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables DNA-binding transcription factor binding activity and transcription coregulator activity. Involved in several processes, including exit from mitosis; regulation of development, heterochronic; and regulation of vulval development. Located in nucleus. Is expressed in several structures, including gonad; hypodermis; pharynx; somatic nervous system; and vulval cell. Orthologous to several human genes including NAB1 (NGFI-A binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mab-10 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 9

Sequence:: Chromosome: II; NC_003280.10 (10528084..10534380)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MAB-10/NAB acts with LIN-29/EGR to regulate terminal differentiation and the transition from larva to adult in C. elegans.
Title: MAB-10/NAB acts with LIN-29/EGR to regulate terminal differentiation and the transition from larva to adult in C. elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R166.1 (e-PCR)
- UniSTS:310575

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coregulator activity	IEA Inferred from Electronic Annotation more info
enables transcription coregulator activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in exit from mitosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in molting cycle process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of development, heterochronic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of vulval development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: NAB transcription cofactor mab-10

NP_496268.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

10528084..10534380

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063867.3 → NP_496268.2 NAB transcription cofactor mab-10 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496268.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q22002

Conserved Domains (2) summary

pfam04904
Location:83 → 161

NCD1; NAB conserved region 1 (NCD1)

pfam04905
Location:396 → 518

NCD2; NAB conserved region 2 (NCD2)