add-1 Adducin-related protein 1;Class II aldolase/adducin N-terminal domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: add-1
Official Full Name: Adducin-related protein 1;Class II aldolase/adducin N-terminal domain-containing protein
Primary source: WormBase:WBGene00000072
Locus tag: CELE_F39C12.2
See related: AllianceGenome:WB:WBGene00000072
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable actin filament binding activity. Involved in actin filament bundle organization; memory; and receptor localization to synapse. Located in postsynaptic density. Is expressed in several structures, including coelomocyte; hypodermis; intestine; nervous system; and pharyngeal-intestinal valve. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; artery disease (multiple); familial combined hyperlipidemia; gastroschisis; and spastic quadriplegic cerebral palsy 3. Orthologous to human ADD1 (adducin 1); ADD2 (adducin 2); and ADD3 (adducin 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See add-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 18

Sequence:: Chromosome: X; NC_003284.9 (4854065..4860045, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F39C12.2 (e-PCR)
- UniSTS:314266

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament bundle organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in barbed-end actin filament capping	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in long-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in receptor localization to synapse	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in short-term memory	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Adducin-related protein 1;Class II aldolase/adducin N-terminal domain-containing protein

NP_001024639.1

Confirmed by transcript evidence

NP_001024640.1

Confirmed by transcript evidence

NP_001024641.1

Confirmed by transcript evidence

NP_001024642.1

Confirmed by transcript evidence

NP_001367832.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

4854065..4860045 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001029469.5 → NP_001024640.1 Adducin-related protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024640.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O44581, Q95X64, Q9U9J9, Q9U9K0

Conserved Domains (1) summary

cl00214
Location:115 → 360

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_001029470.4 → NP_001024641.1 Adducin-related protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024641.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9U9K0

Conserved Domains (1) summary

cl00214
Location:115 → 360

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_001029468.5 → NP_001024639.1 Adducin-related protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024639.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9U9K0

Conserved Domains (1) summary

cl00214
Location:115 → 360

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_001029471.2 → NP_001024642.1 Adducin-related protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024642.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9U9K0

Conserved Domains (1) summary

cl00214
Location:115 → 360

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_001380952.1 → NP_001367832.1 Class II aldolase/adducin N-terminal domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

G8JYB0

Conserved Domains (1) summary

cl00214
Location:115 → 360

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...